Zoldria Injection
By Zoldria
Rx
5ml Injection in a Vial

Composition
Zoledronic acid(4mg)

Manufacturer - Cipla Ltd
Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Expires on or after
January, 2027
About Zoldria Injection
Zoldria Injection, also known as Zoldria 4mg Injection 5 ml, is classified as a bisphosphonate medication used to treat conditions such as osteoporosis, Paget’s bone disease, and high levels of calcium resulting from cancer. Osteoporosis is a bone disorder that leads to weakened and fragile bones, often experienced by post-menopausal women. The active ingredient in Zoldria Injection is Zoledronic acid, which functions by binding tightly to the bone and inhibiting the removal of calcium by osteoclasts, cells responsible for breaking down bone tissue. By preventing excessive breakdown of bones, Zoldria Injection helps maintain bone strength and reduces the likelihood of fractures.
Administration and Dosage:
Zoldria Injection is administered by a healthcare professional, typically a doctor or nurse. The dosage and frequency of injections are determined by your doctor based on your individual needs and underlying condition. Some patients may only require a single injection, while others may need regular injections. Before receiving the injection, it is advised to drink plenty of water to prevent dehydration. It may take some time before the full benefits of the medication are realized. In addition to Zoldria Injection, your treatment plan may involve dietary changes and the use of calcium and vitamin supplements for optimal results.
Side Effects and Precautions:
Common side effects associated with Zoldria Injection include nausea, fatigue, bone pain, constipation, fever, and breathlessness. However, more severe side effects like kidney problems, low calcium levels in the blood, and jaw pain require immediate medical attention. It is crucial to inform your doctor about any existing kidney issues, low calcium levels, pregnancy, or breastfeeding status before starting treatment with Zoldria Injection. Additionally, disclose all other medications you are taking, particularly those used to manage infections, cancer, and osteoporosis, as they may interact with Zoldria Injection. Regular medical tests to monitor kidney function and calcium levels may be necessary throughout the treatment. Smoking and excessive alcohol consumption should be avoided as they can negatively impact bone health.
Warnings:
Zoldria 4mg Injection 5 ml is contraindicated in pregnant or breastfeeding individuals and children under 18 years of age. Individuals with hypocalcemia or severe kidney problems should also avoid using this medication. Driving should be done cautiously as Zoldria 4mg Injection 5 ml may cause dizziness. Osteonecrosis of the jaw (ONJ) is a potential complication associated with Zoldria 4mg Injection 5 ml, and any issues such as loose teeth, oral swelling or pain, non-healing sores, or discharge should be promptly reported to a healthcare provider for assessment and management.
Benefits
Zoldria Injection is a beneficial medication that serves a dual purpose in treating osteoporosis and hypercalcemia. In osteoporosis, a condition prevalent among women after menopause, it acts as a bisphosphonate that slows down the breakdown of bones in the body. By maintaining bone density, this injection effectively reduces the risk of bone fractures. Administered typically once a year for treating osteoporosis and once every two years for prevention, Zoldria Injection complements lifestyle changes such as regular weight-bearing exercise, dietary intake of calcium and Vitamin D, and the reduction of alcohol and tobacco consumption. In cases of hypercalcemia, a condition where excessive calcium is present in the blood, this medication proves valuable by lowering calcium levels through the same mechanism of bone breakdown reduction. Typically given as a one-time injection, additional doses may be necessary. It is crucial to adhere to treatment schedules and follow-up appointments with healthcare providers for optimal results. Moreover, engaging in physical activity, particularly weight-bearing exercises, is recommended to alleviate the impact of hypercalcemia. Patients are advised against using calcium or vitamin D3 supplements and are encouraged to minimize the intake of these nutrients in their diet. Overall, the benefits of Zoldria Injection extend to improving bone strength, reducing fracture risks, and managing calcium levels effectively in the body for better health outcomes.
How to use the Zoldria Injection
When using Zoldria Injection, it is important to follow the guidance of your doctor or nurse, who will be responsible for administering the medication to you. It is crucial not to attempt to self-administer this injection. Your healthcare provider will ensure that the injection is administered correctly and safely, following the appropriate procedures. By allowing a healthcare professional to give you the Zoldria Injection, you can be confident that you are receiving the treatment in the proper manner. Remember, always rely on your doctor or nurse when using this medication to ensure your safety and well-being.
Uses of Zoldria Injection
Zoldria Injection is frequently used in the treatment of osteoporosis and hypercalcemia. Osteoporosis is a condition where bones become weak and brittle, making them more susceptible to fractures. Zoldria Injection helps in strengthening bones and reducing the risk of fractures in individuals with osteoporosis.
Moreover, Zoldria Injection is also beneficial in managing hypercalcemia, a condition characterized by elevated levels of calcium in the blood. By regulating calcium levels, this injection helps in restoring the balance of calcium in the body and thereby alleviating the symptoms associated with hypercalcemia.
In summary, Zoldria Injection is a valuable treatment option for individuals with osteoporosis and hypercalcemia, as it effectively addresses these conditions and promotes better bone health and overall well-being.
What conditions Zoldria Injection treats?
Zoldria Injection is used to treat osteoporosis, a condition where bones become weak and prone to fractures, commonly affecting women after menopause. This medication is a bisphosphonate that slows down bone breakdown, helping to maintain bone density and reduce fracture risks. It is also used for high levels of calcium in cancer patients. Treatment may involve periodic injections, dietary changes, and calcium/vitamin supplements. Common side effects include nausea, bone pain, and anemia. Serious effects like kidney issues and low calcium levels need immediate medical attention. Avoid in pregnancy, inform your doctor of any kidney problems, and monitor kidney function and calcium levels regularly.
Should you consult a doctor?
If you experience serious side effects like kidney problems, low calcium levels, or mouth/jaw pain, seek urgent medical attention. Do not ignore symptoms of dehydration, especially if you are vomiting or have a fever. Contact your doctor immediately if you are pregnant or breastfeeding. Inform your doctor of any existing kidney issues or low calcium levels before taking Zoldria Injection. Seek medical advice if you face persistent side effects such as headache, back pain, musculoskeletal pain, heartburn, diarrhea, or unusual fatigue. Additionally, consult your doctor if you notice ongoing issues like constipation, bone pain, vomiting, or anemia. Remember, certain medications can interact with Zoldria Injection, necessitating frequent tests to monitor kidney function and calcium levels.
Side effects of Zoldria Injection
When using Zoldria Injection, some people may experience side effects as their body gets used to the medication. These side effects are usually mild and go away on their own without needing medical treatment. The possible side effects include headache, back pain, musculoskeletal pain (affecting bones, muscles, or joints), heartburn, diarrhea, nausea, breathlessness, fatigue, constipation, bone pain, vomiting, fever, and anemia (which is a low number of red blood cells). If any of these side effects persist or if you have concerns about them, it's important to consult your doctor for guidance.
Safety advice

liver
Zoldria Injection usage in patients with liver disease has limited information available. It is important to consult your doctor before using this medication. It is advised to seek guidance from a healthcare professional regarding the safety and appropriateness of Zoldria Injection if you have liver issues.

kidney
Limited information is present about using Zoldria Injection in patients with kidney disease. Consult your doctor for guidance.

alcohol
Caution is advised when consuming alcohol with Zoldria Injection. It is important to consult your doctor for guidance on alcohol intake while using this medication.

driving
Zoldria Injection can reduce alertness, impact vision, and cause drowsiness. Avoid driving if experiencing these effects.

pregnancy
Zoldria Injection is not recommended during pregnancy due to potential risk to the baby. Only use if deemed necessary by a doctor in life-threatening cases. Consult your doctor for guidance.

breastfeeding
Zoldria Injection may pose risks during breastfeeding as it could pass into breastmilk and harm the baby based on limited human data.
Consumption warning before consuming Zoldria Injection
Before consuming Zoldria Injection, it is important to note the following warnings. This medication is primarily used to treat osteoporosis caused by menopause or the use of steroids, as well as high levels of calcium in cancer patients. The injection should only be administered by a healthcare professional, and the dosage and frequency will be determined by your doctor based on your condition. Make sure to stay hydrated by drinking plenty of water before the injection.
It may take a few days to experience the full benefits of Zoldria Injection, which is just one part of a treatment plan that may also include dietary changes and supplements. Common side effects like nausea, fatigue, and bone pain may occur. However, serious side effects such as kidney problems and low calcium levels require immediate medical attention. This medication should not be used during pregnancy or breastfeeding, and it's crucial to inform your doctor about any kidney issues or low calcium levels before starting treatment.
Additionally, be sure to disclose all other medications you are taking as they may interact with Zoldria Injection. Regular monitoring of kidney function and calcium levels may be needed. Smoking and excessive alcohol consumption should be avoided as they can impact bone density.
What if you forgot to take Zoldria Injection?
If you miss a dose of Zoldria Injection, it is important to consult your doctor. It is crucial to follow the prescribed dosage schedule to ensure the medication works effectively. Your doctor can provide guidance on the best course of action to take if you forget to take a dose of Zoldria Injection. It is not advisable to double up on doses to make up for a missed one, as this can lead to an overdose. Talking to your doctor will help you understand how to proceed and maintain the effectiveness of your treatment with Zoldria Injection.
Related lab tests
For patients receiving Zoldria Injection, it is important to monitor certain lab tests to assess their health and treatment response accurately. Two key lab tests that are relevant in this regard are Calcium and Intact Parathyroid Hormone levels.
Calcium is an essential mineral that plays a vital role in various bodily functions such as bone health, muscle function, and nerve transmission. Testing calcium levels can help healthcare providers determine if there are any abnormalities such as hypercalcemia (high calcium levels) or hypocalcemia (low calcium levels), which can impact overall health.
Intact Parathyroid Hormone (PTH) is a hormone produced by the parathyroid glands that helps regulate calcium and phosphorus levels in the body. Testing PTH levels can provide insights into parathyroid gland function and conditions such as hyperparathyroidism or hypoparathyroidism, which can affect calcium balance in the body.
Monitoring these lab tests regularly can help healthcare providers track the effectiveness of treatment with Zoldria Injection and ensure optimal health outcomes for patients. In addition to these tests, healthcare providers may recommend other lab tests based on individual patient needs and medical history to provide comprehensive care.
Additional Information
Habit Forming | No |
Chemical Class | Bisphosphonate Derivative |
Therapeutic Class | PAIN ANALGESICS |
Action Class | Bone resorption inhibitor -Bisphosphonates |
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The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.
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Content verified by

Dr. Gowri Kulkarni
MBBS - General Medicine, DNB - Psychiatry, MRCGP [INT] Family Medicine, BSIC (BACP)
Last update on 11-Feb-2025