Xgeva Solution for Injection

By Xgeva

Rx

1 Solution for Injection in a Vial

Composition icon

Composition

Denosumab(120mg)

Manufacturer - Dr Reddy's Laboratories Ltd icon

Manufacturer - Dr Reddy's Laboratories Ltd

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA

Expires on or after icon

Expires on or after

February, 2027

About Xgeva Solution for Injection

Xgeva Solution for Injection is a medication used to treat osteoporosis in postmenopausal women and in men with a higher risk of fractures. It works by strengthening the bones and reducing the chances of fractures occurring. It is important to note that this medicine should only be administered by a healthcare professional and not self-administered. To reap the maximum benefits, it should be used consistently at the same time each day as per your doctor's instructions. Even if you start feeling better, it is crucial to complete the full course of treatment.

To enhance the effectiveness of Xgeva Solution for Injection, it is advised to supplement with adequate amounts of calcium and vitamin D while undergoing treatment. Some common side effects may include pain in extremities, musculoskeletal pain, nerve pain, urinary tract infections, constipation, and rash. If these side effects persist or worsen, it is essential to consult your doctor for guidance on managing or preventing them.

Before beginning treatment with Xgeva Solution for Injection, it is crucial to inform your doctor about all the medications you are currently taking to ensure its safety and efficacy. Pregnant and breastfeeding women should seek advice from their healthcare provider before using this medication.

XGEVA 120MG INJECTION contains Denosumab, a monoclonal antibody used in adults to manage advanced cancer and prevent complications from bone metastasis. It is also helpful in treating giant cell tumors of the bone in adults where surgery is not an option. This medication works by binding to RANKL protein, which is crucial for osteoclast formation and activity, thereby reducing bone resorption and increasing bone strength.

Patients receiving XGEVA 120MG INJECTION may be advised to make lifestyle changes like maintaining good oral hygiene and quitting smoking. Dental examination before starting the treatment is also recommended. However, this medication is not suitable for patients with hypocalcemia or unhealed oral wounds. Pregnant women are advised against its use, and breastfeeding mothers should consult their doctor before starting treatment.

Furthermore, XGEVA 120MG INJECTION is not recommended for children and adolescents under 18 years of age, except for adolescents with giant cell tumors of the bone whose bones have stopped growing. Common side effects may include bone, joint, and muscle pain, shortness of breath, diarrhea, low phosphate levels, and excessive sweating.


Benefits

Xgeva Solution for Injection is a valuable treatment option for individuals suffering from osteoporosis, a condition that weakens bones and increases the risk of fractures, particularly in women after menopause. This medication works by slowing down the breakdown of bone tissue in the body, thereby maintaining bone density and reducing the chances of experiencing a bone fracture. Xgeva is administered by a healthcare professional and should not be self-administered. In addition to receiving the injection, individuals can further benefit from enhancing the strength of their bones by engaging in regular physical activities, particularly weight-bearing exercises, consuming a nutritious diet rich in calcium and Vitamin D, and limiting the intake of alcohol and tobacco. Supplementing with calcium and Vitamin D3 can also play a significant role in improving bone health. With Xgeva Solution for Injection and these lifestyle modifications, individuals can effectively manage osteoporosis and decrease the risk of bone fractures, ultimately leading to better overall bone health and quality of life.


How to use the Xgeva Solution for Injection

When using Xgeva Solution for Injection, it will typically be given to you by a doctor or nurse as a subcutaneous injection, meaning it will be injected under your skin. It's important to also take calcium and vitamin D supplements while receiving treatment with Xgeva. Your doctor will determine the right dosage and how long you should use it based on factors like your age, weight, and the specific condition being treated. It's essential to follow your healthcare provider's instructions carefully to ensure the effectiveness of the treatment and to minimize any potential side effects. If you have any questions or concerns about how to use Xgeva, make sure to discuss them with your doctor or nurse for guidance.


Uses of Xgeva Solution for Injection

Xgeva Solution for Injection is used to treat osteoporosis, a medical condition that weakens bones and increases the risk of fractures. It is also prescribed for adults with giant cell tumors of the bone whose bones have stopped growing. Furthermore, Xgeva is utilized in managing complications resulting from bone metastasis in advanced cancer, which may include fractures and pressure on the spinal cord.


What conditions Xgeva Solution for Injection treats?

Osteoporosis weakens bones, making them fragile and more prone to fractures, often affecting women after menopause. Xgeva Solution for Injection helps by slowing down bone breakdown, maintaining bone density, and reducing fracture risk. It should be administered by a healthcare professional. To enhance its effectiveness, engage in weight-bearing exercises, consume calcium and Vitamin D-rich foods, and limit alcohol and tobacco use. If you experience musculoskeletal, nerve pain, constipation, rash, or urinary tract infection, consult your doctor.


Should you consult a doctor?

It is important to seek medical advice before receiving XGEVA 120MG INJECTION if you have certain conditions. Do not use this medication if you have untreated low calcium levels or unhealed wounds from oral surgery. Inform your doctor if you have any issues with your mouth or teeth such as poor dental health, gum disease, or recent tooth extraction. It is also recommended to disclose if you have not had a dental check-up lately or if you are a smoker, as smoking can lead to increased dental problems. It is important to consult with your healthcare provider to ensure XGEVA 120MG INJECTION is safe for you based on your individual medical history.


Side effects of Xgeva Solution for Injection

When using Xgeva Solution for Injection, some common side effects may occur as your body adjusts to the medication. These could include musculoskeletal pain, pain in extremities, nerve pain, constipation, rash, and urinary tract infections. However, some more serious side effects may also occur that require immediate medical attention. These could include high calcium levels in the blood after treatment stops in certain patients, new or unusual pain in the hip, groin, or thigh (which could indicate a possible thigh bone fracture), rash on the skin or sores in the mouth, severe bone, joint, and muscle pain, shortness of breath, excessive sweating, diarrhea, low phosphate levels in the blood, development of another form of cancer in patients with advanced cancer, and severe allergic reactions. If you experience osteonecrosis (persistent pain, swelling, non-healing sores, discharge in the mouth and/or jaw, numbness of the jaw, or loosening of a tooth) or signs of low calcium levels in the blood (such as muscle spasms, twitches, numbness, or seizures), it is crucial to stop Xgeva and contact your doctor immediately. These side effects should not be ignored, and seeking medical attention promptly is important for proper management and care.


Safety advice

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liver

Xgeva Solution for Injection may be considered safe for individuals with liver disease based on the limited available data. It is indicated that adjusting the dosage of Xgeva Solution for Injection may not be necessary for patients with liver issues. However, it is always recommended to consult with your healthcare provider for personalized advice and guidance regarding the use of Xgeva Solution for Injection.

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kidney

Xgeva Solution for Injection is safe for patients with kidney disease and does not require dosage adjustment.

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alcohol

Caution is advised when drinking alcohol while using Xgeva Solution for Injection. It is recommended to consult your doctor before combining alcohol with this medication.

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driving

Xgeva Solution for Injection generally does not impact your driving ability.

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pregnancy

Xgeva Solution for Injection should not be used during pregnancy due to potential harm. Consult your doctor for guidance, as research has indicated risks to the developing baby in studies involving pregnant women and animals.

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breastfeeding

Xgeva Solution for Injection is likely safe while breastfeeding. Based on limited human data, it does not pose a notable risk to the baby. It is better to consult your doctor before using Xgeva Solution for Injection.


Age below 6 months(Pediatrics)

XGEVA 120MG INJECTION is not recommended for children and adolescents under 18 years of age, except for adolescents with giant cell tumours of the bone whose bones have stopped growing. Consult your doctor before receiving it.

Consumption warning before consuming Xgeva Solution for Injection

Before consuming Xgeva Solution for Injection, it's essential to understand a few important points. This medication is primarily used for treating osteoporosis in postmenopausal women and men at higher risk of fractures. To ensure optimal benefits, this injection should only be administered by a healthcare professional and not by yourself. Consistency is key - take it regularly at the same time daily as prescribed by your doctor, even if you start feeling better.

Along with the treatment, it is advised to intake sufficient calcium and vitamin D supplements to enhance its effectiveness. Be aware of common side effects such as extremity pain, musculoskeletal pain, nerve pain, urinary tract infection, constipation, and rash. If any of these side effects persist or worsen, consult your doctor for further guidance.

Before starting this medication, inform your physician about all other medications you are currently taking to ensure its safety and effectiveness for you. It is crucial for pregnant or breastfeeding individuals to seek medical advice before using Xgeva Solution for Injection.


What if you forgot to take Xgeva Solution for Injection?

If you forget to take a dose of Xgeva Solution for Injection, it is important to speak with your doctor. It is advisable to consult with your healthcare provider for guidance on how to proceed if you have missed a scheduled dose of this medication. Your doctor will be able to provide specific instructions tailored to your individual circumstances. Do not attempt to adjust the dosage or make up for the missed dose without first consulting with your healthcare provider. It is important to follow the advice of your doctor to ensure the effectiveness and safety of your treatment.


What happens if you take overdose of Xgeva Solution for Injection?

Xgeva Solution for Injection, a medication that contains 120mg of the active ingredient, is only to be given to you under the supervision of a doctor or nurse in a hospital setting. This careful administration process significantly reduces the risk of overdose. Nevertheless, if you notice any unusual symptoms after receiving Xgeva, it is crucial to promptly consult your healthcare provider. This proactive approach ensures that any potential concerns are addressed promptly and appropriately.


Related lab tests

When considering the use of Xgeva Solution for Injection, it is important to monitor certain lab tests to ensure the medication is working effectively and your health is being maintained. One key lab test to keep an eye on is the Calcium test. This test checks the levels of calcium in your blood, which is crucial for bone health and various bodily functions. Additionally, the Bone Strength Package is recommended to assess the overall strength and health of your bones. This package may include tests such as the Bone Profile-Advanced, which provides detailed information about your bone health. Other related lab tests to consider are the Basic Bone Care and Advance Bone Care evaluations, which offer insights into your bone density and strength. For individuals dealing with arthritis, the Basic Arthritis Care Plan, Arthritis Profile-Basic, and Arthritis Profile-Advanced tests may be beneficial to monitor joint health and inflammation levels. By regularly monitoring these related lab tests in conjunction with Xgeva treatment, you can stay informed about your bone health and overall well-being.


Additional Information

Habit FormingNo
Chemical ClassMonoclonal Antibody
Therapeutic ClassPAIN ANALGESICS
Action ClassBone resorption inhibitors- Monoclonal antibodies

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Abdullah Khan

MBBS - General Medicine

Last update on 11-Feb-2025