Pirfenex 400mg Tablet

By Pirfenex

Rx

15 Tablet in a Strip

Composition icon

Composition

Pirfenidone(400mg)

Manufacturer - Cipla Ltd icon

Manufacturer - Cipla Ltd

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Expires on or after icon

Expires on or after

January, 2026

About Pirfenex 400mg Tablet

Pirfenex 400 mg Tablet is a medication prescribed for treating idiopathic pulmonary fibrosis (IPF) in adults. IPF is a progressive lung condition characterized by scarring and swelling in the lung tissues, leading to difficulty in breathing deeply. Pirfenex 400 mg Tablet contains Pirfenidone, which helps in reducing scarring and swelling in the lungs by decreasing the release of certain growth factors in the body. This action helps improve breathing and slows down the progression of idiopathic pulmonary fibrosis.

The recommended dosage of Pirfenex 400 mg Tablet is best taken with food at the same time daily to maximize its benefits. The dosage and frequency of intake are determined by the treating doctor based on the individual's condition and symptoms. It is essential to follow the prescribed duration of treatment for optimal results.

While using Pirfenex 400 mg Tablet, some individuals may experience common side effects such as nausea, tiredness, diarrhea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects are temporary and can resolve on their own. However, persistent or severe side effects should be discussed with the doctor.

Before starting Pirfenex 400 mg Tablet, inform your doctor if you have liver or kidney disease, are pregnant, or breastfeeding. It is crucial to disclose all medications being taken as some may interact with Pirfenex, affecting its effectiveness. Patients are advised to take precautions to avoid sun exposure and wear protective clothing or sunscreen while using Pirfenex 400 mg Tablet due to its sun-sensitizing effects.

Pirfenex 400 mg Tablet is not recommended for use in children under 18 years of age and should be used cautiously in elderly patients over 65 years. Patients with severe or end-stage liver or kidney disease should avoid using Pirfenex 400 mg Tablet. Alcohol consumption should be avoided while on this medication, as it can increase dizziness. Smoking and grapefruit juice intake should also be avoided during treatment with Pirfenex 400 mg Tablet to prevent any adverse effects. Regular monitoring and discussions with the doctor are essential to manage potential side effects and ensure the safe and effective use of Pirfenex 400 mg Tablet.


Benefits

Pirfenex 400mg Tablet is a valuable medication specifically designed to address the symptoms of idiopathic pulmonary fibrosis (IPF), a condition wherein the lung tissue becomes thick and stiff, leading to the formation of scar tissue within the lungs. This scarring, known as fibrosis, develops due to a continuous cycle of lung damage and subsequent healing. The irreversible changes associated with IPF can manifest as initial symptoms like shortness of breath or dry cough.

By targeting the root cause of the disease, Pirfenex 400mg Tablet effectively works to reduce the scarring and fibrosis in the lungs. As a result, breathing becomes noticeably easier for individuals suffering from IPF. Clinical studies have shown that Pirfenex 400mg Tablet can significantly slow down the rate of decline in lung function by up to 50%. The mechanism of action involves decreasing the release and activity of naturally occurring growth factors in the body, which in turn helps to alleviate scarring and swelling in the lungs, ultimately improving the overall respiratory function.

Additionally, Pirfenex 400mg Tablet plays a crucial role in slowing down the progression of idiopathic pulmonary fibrosis, offering patients the opportunity to manage their condition more effectively and potentially enhance their quality of life. It is important to note that while using Pirfenex 400mg Tablet, some individuals may experience certain side effects. In such cases, it is highly recommended to have an open discussion with a healthcare provider to address any concerns or uncertainties.

In summary, Pirfenex 400mg Tablet emerges as a beneficial anti-fibrotic medication for adults dealing with idiopathic pulmonary fibrosis, offering the potential to mitigate the impact of the disease and promote better respiratory health.


How to use the Pirfenex 400mg Tablet

To use Pirfenex 400mg Tablet, follow the instructions provided by your doctor. It is important to take this medication in the dose and duration recommended by your healthcare provider. Swallow the tablet whole with a glass of water, preferably with food to avoid any potential stomach upset. Do not chew, crush, or break the tablet before swallowing it. Your physician will determine the appropriate dosage and duration based on factors such as your age, body weight, and the specific condition being treated. It is essential to adhere to your doctor's instructions carefully to ensure the medication is effective and to minimize the risk of side effects. If you have any questions or concerns about using Pirfenex 400mg Tablet, consult your doctor for further guidance.


Uses of Pirfenex 400mg Tablet

Pirfenex 400mg Tablet is used for the treatment of idiopathic pulmonary fibrosis (IPF), a condition that causes progressive scarring in the lungs, leading to difficulty in breathing and reduced lung function. This medication is specifically designed to target and manage the symptoms associated with IPF. It is a valuable option for individuals suffering from this debilitating respiratory disease, as it helps to slow down the progression of fibrosis in the lungs and improve overall lung function. By following the prescribed dosage and recommendations from a healthcare professional, Pirfenex 400mg Tablet can effectively help in managing the symptoms and improving the quality of life for patients with idiopathic pulmonary fibrosis.


What conditions Pirfenex 400mg Tablet treats?

Idiopathic pulmonary fibrosis (IPF) is part of a group of lung diseases where the lung tissues become inflamed and scarred. Over time, this scarring, or fibrosis, thickens and stiffens, making it difficult for the lungs to function well. This can result in decreased lung function, leading to breathlessness and coughing. Symptoms of IPF include shortness of breath, persistent dry cough, loss of appetite, weight loss, and changes in the fingers and toes. These breathing difficulties can cause other health issues.


Should you consult a doctor?

If you experience severe photosensitive reactions to sunlight, such as increased sensitivity or skin rashes, it is advisable to consult your doctor while taking Pirfenex 400mg Tablet. Additionally, smokers should seek medical advice before starting this medication. It is essential to seek a doctor's guidance if you encounter any unusual symptoms or side effects while on Pirfenex 400mg to ensure proper management. Your doctor can assess your condition and recommend appropriate measures to address any concerns related to the medication.


Side effects of Pirfenex 400mg Tablet

When taking Pirfenex 400mg Tablet, you may experience a range of side effects. Common side effects that may occur and usually subside as your body gets used to the medication include insomnia, headache, dizziness, tiredness, sinus inflammation, loss of appetite, upper respiratory tract infection, weight loss, nausea, indigestion, diarrhea, and photosensitivity. It is important to consult your doctor if these side effects persist or if you have concerns about them.

In some cases, more severe side effects may occur, and you should stop taking Pirfenex 400mg Tablet and contact your doctor immediately if you experience any of the following: signs of angioedema or serious allergic reactions such as urticaria, itching, swelling of the face, lips, tongue, or throat causing difficulty in breathing or feeling faint; signs of abnormal liver function like yellowish discoloration of the skin, dark urine, itching, pain on the upper right side of the abdomen, loss of appetite, bleeding or bruising more easily, and tiredness; signs and symptoms of Stevens-Johnson syndrome or toxic epidermal necrolysis, including fever, flu-like symptoms, reddish or circular patches on the trunk with central blisters, peeling of the skin, and ulcers on the mouth, throat, eyes, nose, and genitals.

Other potential side effects may include infections of the throat or airways, sinusitis, influenza, common cold, stomach problems like acid reflux, vomiting, constipation, and stomach upset, decreased appetite, difficulty sleeping, shortness of breath, joint pain, bladder infections, changes in taste sensation, hot flushes, bloating, abdominal pain, heartburn, flatulence, elevated liver enzymes, sunburn or skin reactions from sun exposure, skin problems like rashes, itchy skin, redness, dry skin, muscle pain, weakness, chest pain, and feeling low on energy. If you experience any of these severe side effects, prompt medical attention is necessary.


Safety advice

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liver

When using Pirfenex 400mg Tablet, it's important to be cautious if you have liver disease. Patients with liver issues may require adjustments in the dosage of Pirfenex 400mg Tablet, so consulting your doctor before using this medication is crucial. It is not advisable to use Pirfenex 400mg Tablet in individuals with severe liver disease. Protect your liver health by seeking medical advice before starting treatment with Pirfenex 400mg Tablet.

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kidney

Pirfenex 400mg Tablet needs caution in patients with kidney disease. Adjustment of dosage may be necessary. Avoid in severe kidney disease and dialysis patients. Consult your doctor.

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alcohol

Consult your doctor when consuming alcohol with Pirfenex 400mg Tablet.

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driving

Pirfenex 400mg Tablet can reduce alertness, impact vision, or cause drowsiness and dizziness. If these effects occur, avoid driving.

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pregnancy

Pirfenex 400mg Tablet may not be safe during pregnancy as animal studies suggest potential harm to the baby. Consult your doctor for a thorough evaluation before using.

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breastfeeding

It is better to consult your doctor before using Pirfenex 400mg Tablet during breastfeeding.


Age above 75(Geriatrics)

PIRFENEX 400MG should be taken with caution in elderly patients (above 65 years of age) Your doctor will decide the dose, duration of the treatment and its frequency for you depending on the severity of your existing condition and other comorbid diseases.

Age below 6 months(Pediatrics)

PIRFENEX 400MG is not recommended for use in children and adolescents under 18 years of age. Contact child’s doctor for advice.

Consumption warning before consuming Pirfenex 400mg Tablet

Before taking Pirfenex 400mg Tablet 15's, do not use it if you are allergic to any of its components, have severe liver impairment or kidney disease requiring dialysis, or are taking fluvoxamine. Inform your doctor if you have conditions like photosensitivity, smoke, or have kidney/liver problems. Prior to use during pregnancy or breastfeeding, consult your doctor. Be cautious as Pirfenex 400mg Tablet 15's may cause tiredness and dizziness, affecting your ability to drive. Avoid alcohol consumption with this medication as it may increase dizziness. Not recommended for children under 18 years due to lack of established safety and effectiveness.


Disease interactions

When taking Pirfenex 400mg Tablet, it's crucial to inform your doctor if you have severe liver (hepatic) issues or if you are at an advanced stage of kidney (renal) impairment that requires dialysis. These conditions can impact how your body processes the medication, potentially affecting its effectiveness or causing adverse reactions. By sharing this information with your healthcare provider, they can adjust your treatment plan accordingly to ensure your safety and the best possible outcome.


What happens if you take overdose of Pirfenex 400mg Tablet?

When you take more than the prescribed amount of Pirfenex 400mg Tablet, it is considered an overdose. An overdose can happen if you or someone else accidentally takes too much of the medication. In case of an overdose, it is crucial to seek immediate medical help. Contact your doctor right away or go to the nearest hospital for assistance. It is important to address an overdose promptly to minimize any potential risks or complications.


Related lab tests

For patients taking Pirfenex 400mg Tablet, it is important to monitor their liver health through liver function tests. These tests help to assess the functioning of the liver and detect any potential liver damage or side effects caused by the medication. Some related lab tests that may be recommended for patients on Pirfenex 400mg Tablet include:

1. Liver Enzymes Test (AST, ALT): This test measures the levels of enzymes in the liver that can indicate liver inflammation or damage.

2. Bilirubin Test: Bilirubin is a waste product that the liver processes and excretes. Abnormal levels of bilirubin can suggest liver dysfunction.

3. Albumin Test: Albumin is a protein produced by the liver, and low levels may indicate liver disease or damage.

4. Prothrombin Time (PT) Test: This test measures how long it takes for blood to clot and can be affected by liver function.

Regular monitoring of these lab tests can help healthcare providers ensure the liver is functioning properly and detect any issues early on. It is important for patients to follow their healthcare provider's recommendations for monitoring liver function while taking Pirfenex 400mg Tablet.


Additional Information

Habit FormingNo
Chemical ClassPyridones Derivative
Therapeutic Class-
Action ClassIdiopathic pulmonary fibrosis (IPF)

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Upasana Bhatia

MBBS - General Medicine

Last update on 11-Feb-2025