Mesacol Enema
By Mesacol
Rx
60ml Enema in a Boxes

Composition
Mesalazine(4gm)

Manufacturer - Sun Pharmaceutical Industries Ltd
Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Expires on or after
April, 2026
About Mesacol Enema
Mesacol Enema is a medication classified as an anti-inflammatory drug aimed at addressing ulcerative colitis and ulcerative proctitis, both of which are inflammatory conditions affecting the bowel. Ulcerative colitis is characterized by inflammation and ulcers in the lining of the colon, often leading to symptoms like bleeding and discharge of pus and mucus. Mesacol Enema 60 ml contains Mesalamine, the active ingredient that works to prevent the production of chemical messengers causing inflammation in the intestines, thereby reducing ulceration, bleeding, and stomach pain associated with these conditions.
It is important to follow the guidance of your physician when using Mesacol Enema. The medication is specifically designed for rectal administration and should not be taken orally. After inserting the enema, it is advisable to remain in a lying position for at least 15 minutes. Dosage instructions should be strictly adhered to as prescribed by your doctor, and the medication should be continued for the recommended duration to prevent symptoms from recurring or worsening prematurely.
While using Mesacol Enema, some individuals may experience mild side effects such as rectal discomfort, rash, itching, or fever. If these side effects persist, worsen, or become bothersome, it is crucial to inform your healthcare provider for further guidance. Before initiating treatment with Mesacol Enema, inform your doctor of any existing kidney or liver issues, stomach blockages, or pregnancy/breastfeeding status. Additionally, provide details of all other medications you are currently taking, as certain interactions may occur.
It is emphasized that Mesacol Enema should not be used by individuals allergic to Mesalamine or related compounds. Patients with severe kidney or liver disease should avoid using this medication. Pregnant and breastfeeding women should only use Mesacol Enema if deemed absolutely necessary by their healthcare provider, weighing the potential benefits against risks. Children and adolescents under 18 years of age are not recommended to use this medication, and caution is advised for elderly patients over 65 years, with doctor consultation.
Common side effects associated with Mesacol Enema include abdominal pain, nausea/vomiting, diarrhea, rash, headache, rectal discomfort, and irritation at the application site. It is essential to consult your doctor if these symptoms worsen or cause significant discomfort during the course of treatment.
Benefits
Mesacol Enema is a medication that offers multiple benefits in the treatment of ulcerative colitis, a condition that causes inflammation in the colon and rectum. By containing Mesalamine, an anti-inflammatory drug, Mesacol Enema effectively relieves symptoms such as bleeding, frequent diarrhea, and abdominal pain associated with ulcerative colitis. By inhibiting the production of certain chemical substances that cause pain and swelling, it helps reduce inflammation in the intestines. This medication not only provides relief from discomfort but can also prevent further episodes of ulcerative colitis. When administered through the rectal route, Mesacol Enema is particularly effective in treating symptoms that affect the rectum directly. It is essential to use Mesacol Enema regularly and drink plenty of fluids to ensure maximum effectiveness and maintain hydration. With its ability to relieve symptoms and prevent their recurrence, Mesacol Enema proves to be a valuable treatment option for individuals suffering from ulcerative colitis.
How to use the Mesacol Enema
To use Mesacol Enema, follow your doctor's instructions carefully. This medication is meant for rectal use only, so do not attempt to self-administer it. Before using the enema, make sure to empty your bowels if needed and wash your hands thoroughly. Shake the bottle for at least 30 seconds and remove the protective cap from the applicator. While lying on your left side with your left leg straight and right leg bent, insert the lubricant-coated applicator into the rectum with the bottle pointed towards your navel. Gently squeeze the bottle until it is empty, then remove the applicator from the rectum. Stay in this position for at least 30 minutes to allow the medicine to disperse throughout the lower part of the large intestine. Remember to wash your hands after using the enema and avoid emptying your bowels until the next morning. The correct dose and duration of Mesacol Enema will be determined by your doctor based on factors such as your age, weight, and medical condition. Follow these steps precisely for the best results.
Uses of Mesacol Enema
Mesacol Enema is primarily used in treating ulcerative colitis and ulcerative proctitis. Both conditions involve inflammation of the gut lining. This medication is specifically designed to address the inflammation brought on by conditions like ulcerative colitis, which is a chronic inflammatory bowel disease. Mesacol Enema is utilized to alleviate the symptoms associated with these conditions and promote healing within the affected individuals.
What conditions Mesacol Enema treats?
Mesacol Enema is used to treat ulcerative colitis, a chronic inflammatory bowel disease that causes inflammation and ulcers in the colon. Symptoms include bloody stools, stomach pain, diarrhoea, rectal pain, and weight loss. Factors like immune disorders, genetic predisposition, and environmental triggers may contribute to ulcerative colitis. It can also lead to additional issues such as joint pain, mouth sores, and decreased appetite. Medications and lifestyle changes are commonly used to manage ulcerative colitis.
Should you consult a doctor?
Seek medical attention immediately if you experience any unusual symptoms after using Mesacol Enema, especially if you have a medical condition that makes you prone to bleeding. It is important to consult your doctor before using Mesacol Enema, especially if you are below 18 years old as it is not recommended for children and adolescents. If you or your child experience any adverse effects or if there is no improvement in your condition after using Mesacol Enema, do not hesitate to seek guidance from a healthcare professional. Your doctor can provide the best advice based on your individual health needs.
Side effects of Mesacol Enema
Most side effects of Mesacol Enema are usually mild and temporary, as your body gets used to the medication. These may include rectal discomfort, flatulence, headache, vomiting, diarrhea, nausea, abdominal pain, and rash. Some individuals may also experience stomach pain, indigestion, muscle aches, and dizziness. In rare cases, serious side effects may occur requiring immediate medical attention. These include signs of inflammation of the heart or pancreas, serious skin reactions like Stevens-Johnson syndrome, allergic reactions such as difficulty in breathing or skin rashes, signs of a blood disorder such as unexplained bleeding or bruising, signs of kidney problems like changes in urine color or amount, sudden abdominal cramps or pain, fever, severe headache, and rash. If you experience any of these severe side effects, stop using Mesacol Enema and seek medical advice promptly. It is always recommended to consult your doctor if you have concerns about any side effects or if they persist.
Safety advice

liver
Mesacol Enema should be approached with caution in individuals with liver disease. It may be necessary to adjust the dosage of Mesacol Enema in such cases. It is important to consult your doctor before using this medication to ensure it is safe and appropriate for your particular liver health situation.

kidney
Mesacol Enema should be used with caution in patients with kidney disease. Dose adjustment may be required, and consulting with your doctor is advised. It is not recommended for use in patients with severe kidney disease.

alcohol
No interaction is known between alcohol and Mesacol Enema. Always consult your doctor regarding alcohol consumption during Mesacol Enema usage. If pregnant, consult your healthcare provider.

driving
When using Mesacol Enema, no interactions affecting driving have been found or established. Drive carefully as usual.

pregnancy
Mesacol Enema may not be safe to use during pregnancy. Animal studies have shown harm to the developing baby. Your doctor will assess the benefits and risks before prescribing. Consult your doctor for guidance.

breastfeeding
Mesacol Enema may not be safe while breastfeeding, as it could potentially pass into breastmilk and harm the baby. If using this medication, observe your baby for signs of diarrhea.
Age above 75(Geriatrics)
Consumption warning before consuming Mesacol Enema
Before using Mesacol Enema 60 ml, it is crucial to inform your doctor about all your medical conditions, sensitivities, and current medications. Avoid using Mesacol Enema 60 ml if you are pregnant, planning pregnancy, or breastfeeding without consulting your doctor first. Individuals with severe renal or hepatic impairment should not use Mesacol Enema 60 ml unless advised by a healthcare professional. Stick to the prescribed dose and duration of Mesacol Enema 60 ml as directed by your doctor. Never swallow Mesacol Enema 60 ml; if accidental ingestion occurs, drink plenty of water and seek immediate medical assistance.
Disease interactions
Mesacol Enema, a medication available in a 60 ml form, is known to interact with certain disease conditions. It is crucial to be cautious when using Mesacol Enema if you have severe impairment of hepatic (liver) or renal (kidney) function. Patients with these conditions may experience altered effects of the medication, which can pose risks to their health. Additionally, individuals with a rare blood condition known as porphyria should also avoid using Mesacol Enema without proper medical guidance. Due to potential interactions and risks involved, it is essential to consult with a healthcare provider before using Mesacol Enema if you have any of these mentioned disease conditions.
What if you forgot to take Mesacol Enema?
If you happen to miss a dose of Mesacol Enema, try to use it as soon as you remember. But if it's almost time for your next scheduled dose, it's best to skip the missed dose and continue with your usual dosing schedule. Avoid taking a double dose to make up for the missed one. It's important to maintain a consistent routine with your medication to ensure its effectiveness.
What happens if you take overdose of Mesacol Enema?
In case of accidental overdose of Mesacol Enema, it is crucial to seek immediate medical assistance either by contacting your doctor or going to the nearest hospital. Overdosing on this medication can lead to symptoms that require prompt management. It is important to act swiftly to address any potential complications that may arise from taking too much Mesacol Enema.
Related lab tests
Related Lab Tests for monitoring the effectiveness of Mesacol Enema may include Anti Neutrophilic Cytoplasmic Antibody test, C-Reactive Protein Quantitative test, and Erythrocyte Sedimentation Rate test. These lab tests help in assessing the inflammatory response in the body, especially in the gastrointestinal tract. In addition, procedures like Colonoscopy and Sigmoidoscopy can also be recommended to visualize the colon and rectum for any signs of inflammation or disease activity. These tests and procedures are important tools in the management of conditions for which Mesacol Enema is prescribed.
Additional Information
Habit Forming | No |
Chemical Class | Aminosalicylic Acids Derivative |
Therapeutic Class | - |
Action Class | 5- Aminosalicylic acid (5-ASA) |
FAQs
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Content verified by

Dr. Gowri Kulkarni
MBBS - General Medicine, DNB - Psychiatry, MRCGP [INT] Family Medicine, BSIC (BACP)
Last update on 11-Feb-2025