Macorate CR 500 Tablet
By Macorate
Rx
10 Tablet PR in a Strip

Composition
Magnesium Valproate(500mg)

Manufacturer - Sun Pharmaceutical Industries Ltd
Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Expires on or after
July, 2026
About Macorate CR 500 Tablet
Macorate CR 500 Tablet is classified as an anti-epileptic medication that falls under the category of anticonvulsants. It is primarily prescribed for the treatment of epilepsy, bipolar disorder, and the prevention of migraine headaches. Epilepsy is a neurological disorder characterized by abnormal brain activity leading to recurrent seizures. Macorate CR 500 Tablet contains Valproic acid, a compound that helps regulate excessive and irregular nerve activity in the brain, thereby aiding in seizure control.
Additionally, Macorate CR 500 Tablet is utilized to manage manic episodes associated with bipolar disorder. This medication works by increasing the levels of a chemical known as GABA, which plays a crucial role in inhibiting nerve communication throughout the brain, resulting in a calming effect. By limiting the transmission of nerve pain, Macorate CR 500 Tablet also assists in preventing migraine headaches.
It is essential to follow your doctor's instructions precisely when taking Macorate CR 500 Tablet. The dosage may be adjusted gradually until your condition stabilizes. It is crucial to maintain regular intake of the medication, even if you start feeling better, as stopping abruptly could lead to increased seizures or worsened symptoms of bipolar disorder.
Some common side effects of Macorate CR 500 Tablet may include skin rashes, headaches, nausea, sleep disturbances, dizziness, and drowsiness. These side effects are usually temporary and tend to subside on their own. However, if these symptoms persist or become bothersome, it is advisable to consult your doctor for appropriate guidance.
Before initiating treatment with Macorate CR 500 Tablet, it is important to inform your healthcare provider about any existing kidney or liver issues, meningitis, depression, or suicidal thoughts. Moreover, disclose all other medications you are currently taking, including contraceptives, as interactions may occur. Pregnant women should avoid this medication due to potential risks of congenital defects, and breastfeeding mothers should consult their doctor before use.
Due to the potential for drowsiness and dizziness as side effects, it is recommended to refrain from activities such as driving or operating machinery while on Macorate CR 500 Tablet. Regular monitoring through blood tests may be required to assess your response to the medication and ensure its effectiveness in managing your condition.
Benefits
Macorate CR 500 Tablet offers several benefits in treating various conditions. In epilepsy or seizures, this medication helps prevent and control seizures by reducing the nerve impulses that trigger them. By managing the frequency of seizures, it enables individuals to engage in daily activities with greater confidence. Symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and feelings of fear or anxiety can be reduced with the use of Macorate CR 500 Tablet. Importantly, this medication is not linked to physical or psychological dependence, but it should be taken regularly as prescribed to be effective. Missing doses may lead to seizure triggers.
Moreover, in the prevention of migraines, the exact mechanism of how Macorate CR 500 Tablet works is not fully understood. However, it is believed to modulate abnormal nerve cell activity in the brain or enhance activity in a brain region associated with migraines. By preventing and reducing the frequency of headaches, this medication supports individuals in carrying out their everyday tasks and achieving a better quality of life.
Furthermore, Macorate CR 500 Tablet is beneficial in managing bipolar disorder by restoring the normal balance of nerve activity in the brain. By helping to prevent extreme mood swings and reducing agitation, it may result in fewer episodes of low mood. Although it can take some weeks for the medication to take effect, it is recommended to continue treatment for at least six months or longer as advised by a healthcare provider. Consistent intake is crucial for its effectiveness, and individuals should not discontinue the medication without medical guidance. Maintaining a healthy lifestyle with proper nutrition and regular exercise can also aid in reducing symptoms of bipolar disorder.
How to use the Macorate CR 500 Tablet
When using Macorate CR 500 Tablet, it is important to follow your doctor's instructions or the directions on the label carefully. You can take this tablet with or without food, but it is recommended to take it at the same time each day for better results. When taking the tablet, swallow it whole with a glass of water; do not crush, break, or chew it as this may affect its effectiveness.
If you are using the oral suspension or syrup form of Macorate CR 500, remember to shake the bottle well before each use to ensure the medication is properly mixed. Take the prescribed dose by mouth using the measuring cup, dosing syringe, or dropper provided with the medication. This will help you to accurately measure the right amount of medication for your dose.
Following these simple steps will ensure that you are using Macorate CR 500 Tablet correctly and getting the most benefit from your treatment. Remember to always consult your doctor if you have any questions or concerns about how to use this medication.
Uses of Macorate CR 500 Tablet
Macorate CR 500 Tablet is commonly used to treat epilepsy, which is a condition characterized by recurrent seizures or fits. It is also beneficial in the prevention of migraines, a type of severe headache often accompanied by sensitivity to light and sound. Additionally, this medication is effective in managing bipolar disorder, a mental health condition marked by extreme mood swings ranging from depressive lows to manic highs. Overall, Macorate CR 500 Tablet is utilized to address epilepsy, migraines, and bipolar disorder.
What conditions Macorate CR 500 Tablet treats?
Macorate CR 500 Tablet is commonly used to manage epilepsy, a nervous system disorder characterized by disturbed nerve cell activity in the brain. Epilepsy causes recurrent seizures due to imbalanced electrical rhythms in the brain, leading to disruptions in consciousness, movements, or sensations. Seizures can be generalized or partial, affecting either the entire brain or only a part of it. These seizures may result in uncontrollable muscle cramps, spasms, confusion, or unconsciousness. Various factors such as high fever, trauma, genetic disorders, brain injuries, or strokes can contribute to the development of epilepsy.
Should you consult a doctor?
If you experience persistent side effects such as headaches, dizziness, blurred vision, loss of appetite, nausea, vomiting, sleepiness, hair loss, weight gain, double vision, diarrhea, impaired coordination, tremors, weakness, stomach pain, or increased appetite while taking Macorate CR 500 Tablet, it is advisable to seek medical advice. Additionally, if you have kidney or liver problems, meningitis, depression, or suicidal thoughts, consult your doctor before starting this medication. Inform your healthcare provider about all other medications you are using as some may interact with Macorate CR 500 Tablet. It is crucial to avoid driving or operating machinery if you feel drowsy or dizzy while on this medication. Regular monitoring and blood tests may be necessary to evaluate your response to the treatment. Any concerns or persistent symptoms should be discussed with your healthcare provider to ensure your well-being.
Side effects of Macorate CR 500 Tablet
When taking Macorate CR 500 Tablet, you may experience some side effects. Most of these side effects are usually mild and tend to go away as your body gets used to the medication. However, if any of these effects persist or cause concern, it's important to consult your doctor. Some common side effects of Macorate CR 500 Tablet include headaches, dizziness, blurred vision, loss of appetite, nausea, vomiting, sleepiness, hair loss, weight gain, double vision, diarrhea, impaired coordination, tremors, weakness, stomach pain, and increased appetite. Additionally, you may also notice stomach pain, feelings of sickness, diarrhea, dry or sore mouth, swollen gums, tremors in a part of your body, unusual eye movements, fatigue, changes in hair such as thinning or texture, and irregular or delayed periods. If you experience any of these effects and they persist or become bothersome, seek medical advice.
Safety advice

liver
Macorate CR 500 Tablet may not be safe for individuals with liver disease and it is advisable to avoid using this medication. It is recommended to consult your doctor before taking Macorate CR 500 Tablet if you have any liver issues.

kidney
Caution Macorate CR 500 Tablet requires caution in patients with kidney disease. Adjusting the dose may be necessary. Consult with your doctor for guidance.

alcohol
It is not known whether it is safe to consume alcohol with Macorate CR 500 Tablet. Please consult your doctor.

driving
When taking Macorate CR 500 Tablet, be cautious as it may reduce alertness, cause vision changes, or induce drowsiness and dizziness. Avoid driving if you experience these symptoms.

pregnancy
Macorate CR 500 Tablet is considered unsafe during pregnancy due to potential risk to the developing baby. In rare life-threatening situations, a doctor may prescribe it if benefits outweigh risks. Consult your doctor before use.

breastfeeding
Macorate CR 500 Tablet is likely unsafe for breastfeeding mothers. Limited human data indicates it may transfer into breastmilk and harm the baby.
Consumption warning before consuming Macorate CR 500 Tablet
Before you start taking Macorate CR 500 Tablet, it is crucial to inform your doctor about all your medical conditions, allergies, and medications you are currently taking. Make sure to disclose if you are pregnant, think you might be pregnant, planning to conceive, or if you are breastfeeding. It is advised not to get pregnant while using Macorate CR 500 Tablet, and consult your doctor immediately if you do become pregnant. Avoid consuming alcohol while on this medication, as it can have adverse effects. Additionally, it is important not to drive or operate machinery while taking Macorate CR 500 Tablet to ensure your safety and the safety of others.
Disease interactions
When considering the interactions of Macorate CR 500 Tablet with various diseases, it is crucial to communicate openly with your healthcare provider about any existing health conditions. Patients with depression, liver disease, urea cycle disorders, suicidal tendencies, HIV disease, hereditary mitochondrial disorders, or thrombocytopenia (low platelets) should inform their doctor before starting this medication. This transparency is important for the safe and effective use of Macorate CR 500 Tablet.
What if you forgot to take Macorate CR 500 Tablet?
If you forget to take a dose of Macorate CR 500 Tablet, try to take it as soon as you remember. But if it's nearly time for your next dose, just skip the missed one and stick to your normal dosing schedule. It's important not to take a double dose to make up for the missed one.
Additional Information
Habit Forming | No |
Chemical Class | - |
Therapeutic Class | NEURO CNS |
Action Class | Sodium channel modulators (AED) |
FAQs
Disclaimer
The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.
₹170
Inclusive of all taxes
Content verified by

Dr. Gowri Kulkarni
MBBS - General Medicine, DNB - Psychiatry, MRCGP [INT] Family Medicine, BSIC (BACP)
Last update on 11-Feb-2025