Kombiglyze XR 5mg/500mg Tablet

By Kombiglyze

Rx

7 Tablet XR in a Strip

Composition icon

Composition

Saxagliptin(5mg) + Metformin(500mg)

Manufacturer - AstraZeneca icon

Manufacturer - AstraZeneca

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore

Expires on or after icon

Expires on or after

March, 2026

About Kombiglyze XR 5mg/500mg Tablet

Kombiglyze XR 5mg/500mg Tablet is a combination medication used to manage type 2 diabetes mellitus by controlling high blood sugar levels. It is essential in preventing severe diabetes complications like kidney damage, blindness, heart attacks, or strokes. The tablet can be prescribed alone or in conjunction with other diabetes medications and is most effective when combined with a healthy diet and regular exercise routine.

This medication contains Saxagliptin and Metformin, which work together to regulate blood glucose levels. Saxagliptin blocks an enzyme known as DPP-4, aiding in insulin production only when needed and reducing excess glucose from the liver. Metformin, on the other hand, lowers glucose output from the liver, slows glucose absorption, and enhances insulin response. By preventing blood glucose from reaching dangerously high levels, it helps keep diabetes under control.

It is crucial to take Kombiglyze XR 5mg/500mg Tablet regularly, at the same time each day, as prescribed by your doctor. Taking it with meals can help reduce the risk of stomach upset. The common side effects of this medication include diarrhea, nausea, vomiting, headache, and sore throat. Low blood sugar levels may occur, especially if used with other diabetes drugs like insulin, so it's important to be aware of and manage hypoglycemia symptoms.

Before taking Kombiglyze XR 5mg/500mg Tablet, inform your doctor about any prior kidney, liver, or heart conditions, pancreas issues, excessive alcohol consumption, or if you are pregnant or breastfeeding. Additionally, disclose all medications you are taking to avoid potential interactions. Regular monitoring of kidney function and blood sugar levels is essential during treatment. Remember that lifestyle choices, including diet and exercise, are key to effectively managing diabetes.

It's important not to cease taking Kombiglyze XR 5mg/500mg Tablet abruptly, even if you feel better, as it could lead to increased sugar levels and worsen diabetes-related complications. This medication is not suitable for individuals with severe kidney or liver disease and should not be given to children under 18 years old. Special caution is advised if taking digoxin alongside this medication due to potential drug interactions. Follow your doctor's recommendations and report any persisting or worsening side effects promptly.


Benefits

Kombiglyze XR 5mg/500mg Tablet offers several benefits in the treatment of Type 2 diabetes mellitus. This medication combines two powerful medicines, Saxagliptin and Metformin, which work together to lower blood glucose levels. Maintaining optimal blood glucose levels is crucial in managing diabetes as it can help reduce the risk of serious complications such as kidney damage, eye damage, nerve problems, and loss of limbs. By effectively controlling blood sugar levels, Kombiglyze XR 5mg/500mg Tablet also plays a key role in lowering the risk of heart disease and stroke.

When used regularly in combination with a proper diet and exercise regimen, Kombiglyze XR 5mg/500mg Tablet can help individuals lead a normal and healthy life. This medication is designed to keep blood sugar levels in check and is most effective when accompanied by healthy lifestyle changes such as weight loss, regular exercise, and a balanced diet. By taking Kombiglyze XR 5mg/500mg Tablet as prescribed, patients can significantly reduce the chances of developing complications associated with diabetes, including retinopathy (eyesight loss), nephropathy (kidney issues), neuropathy (nerve damage), diabetic foot ulcer, and delayed wound healing.

Overall, the benefits of Kombiglyze XR 5mg/500mg Tablet extend beyond just lowering blood sugar levels - they encompass the prevention of severe diabetes-related complications and the promotion of long-term health and well-being. It is essential to adhere to the prescribed treatment plan with this medication to safeguard future health and enjoy a higher quality of life.


How to use the Kombiglyze XR 5mg/500mg Tablet

To use Kombiglyze XR 5mg/500mg Tablet, follow your doctor's instructions carefully. Take the tablet as a whole, without chewing, crushing, or breaking it. It is recommended to swallow the tablet with a glass of water. It is best to take Kombiglyze XR 5mg/500mg Tablet with food; preferably with or after meals. Your doctor will determine the right dosage and duration of treatment based on factors like your age, weight, and medical condition. It is important not to stop taking Kombiglyze XR 5mg/500mg Tablet unless advised by your doctor. If you have any concerns or questions about how to take this medication, consult your physician for guidance.


Uses of Kombiglyze XR 5mg/500mg Tablet

Kombiglyze XR 5mg/500mg Tablet is intended for the treatment of Type 2 diabetes mellitus, also known as non-insulin-dependent diabetes. This medication is specifically designed to help manage Type 2 diabetes mellitus. It plays a crucial role in effectively regulating blood sugar levels in individuals with this condition.


What conditions Kombiglyze XR 5mg/500mg Tablet treats?

Type 2 diabetes is a condition where the body struggles to produce enough insulin or use the insulin effectively. This results in high blood sugar levels, leading to symptoms such as increased thirst, frequent urination, hunger, fatigue, and blurry vision. Type 2 diabetes can also cause complications like nerve issues, kidney problems, eye damage, limb amputation, sexual problems, and a higher risk of heart attack or stroke.


Should you consult a doctor?

It is important to seek medical attention if you experience any of the following conditions while taking Kombiglyze XR 5mg/500mg Tablet: severe, uncontrollable diabetes, diabetic coma or precoma, nausea, vomiting, diarrhea, rapid weight loss, lactic acidosis or ketoacidosis, dehydration, severe systemic infections, shock, blood circulation problems, or if you are an alcoholic.

Before starting Kombiglyze XR 5mg/500mg Tablet, inform your doctor if you have type I diabetes mellitus, require surgery, or have a history of pancreatic disease.

If you encounter any of the mentioned conditions or have the mentioned medical history, it is advised to consult your healthcare provider promptly to ensure safe and effective use of Kombiglyze XR 5mg/500mg Tablet.


Side effects of Kombiglyze XR 5mg/500mg Tablet

Side effects of Kombiglyze XR 5mg/500mg Tablet can occur but may not always need medical attention as your body adapts to the medication. Common side effects include nausea, vomiting, diarrhea, and hypoglycemia (low blood glucose level). You may also experience reduced appetite, urinary tract infections, and inflammation of the throat and nasal passages known as nasopharyngitis. Other potential side effects encompass dizziness, sweating, palpitations, dry mouth and skin, as well as joint pain and erectile dysfunction. Additional symptoms could include headaches, muscle pain, changes in taste, stomach discomfort like indigestion and bloating, along with various infections such as of the airways, sinuses, and stomach. If these side effects persist or cause concern, it's advisable to consult your healthcare provider for guidance.


Safety advice

scroll

liver

Taking Kombiglyze XR 5mg/500mg Tablet if you have liver disease is not recommended. It is likely unsafe for individuals with liver issues, so it is best to avoid using this medication. It is crucial to consult your doctor before considering the use of Kombiglyze XR in order to ensure your safety and well-being.

scroll

kidney

Kombiglyze XR 5mg/500mg Tablet may not be safe for patients with kidney disease. Consult your doctor before use.

scroll

alcohol

It is not safe to mix alcohol with Kombiglyze XR 5mg/500mg Tablet.

scroll

driving

When taking Kombiglyze XR 5mg/500mg Tablet, be cautious when driving. Low or high blood sugar levels can impact your ability to drive safely. If you experience symptoms, avoid driving.

scroll

pregnancy

Kombiglyze XR 5mg/500mg Tablet is not recommended during pregnancy due to potential harm to the developing baby based on animal studies. Consult your doctor for a thorough evaluation before using.

scroll

breastfeeding

Kombiglyze XR 5mg/500mg Tablet may not be safe to use while breastfeeding. There is limited data indicating that the drug could pass into breastmilk and potentially harm the infant.


Age above 75(Geriatrics)

KOMBIGLYZE XR 5/500MG TABLET should be used with caution among the elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Age below 6 months(Pediatrics)

KOMBIGLYZE XR 5/500MG TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Consumption warning before consuming Kombiglyze XR 5mg/500mg Tablet

Before consuming Kombiglyze XR 5mg/500mg Tablet 7's, it is crucial to be aware of potential risks. Prolonged use of this medication may lead to acute pancreatitis and kidney issues. There is also a heightened chance of experiencing hypoglycemia when Kombiglyze XR 5mg/500mg Tablet 7's is combined with other anti-diabetic medications or insulin. In such instances, a physician may need to adjust the dosage to ensure safety. Additionally, severe allergic reactions such as anaphylaxis, angioedema, and skin conditions like Stevens-Johnson syndrome have been reported in some patients taking this medication. It is essential to consult with a healthcare provider before starting Kombiglyze XR 5mg/500mg Tablet 7's to understand and manage these potential risks effectively.


What if you forgot to take Kombiglyze XR 5mg/500mg Tablet?

If you forget to take a dose of Kombiglyze XR 5mg/500mg Tablet, the best thing to do is to take it as soon as you remember. But, if it's close to the time for your next dose, it's better to skip the missed dose and continue with your normal dosing schedule. Never take a double dose to make up for the one you missed.


What happens if you take overdose of Kombiglyze XR 5mg/500mg Tablet?

In the event that you or someone else unintentionally takes too much of the Kombiglyze XR 5mg/500mg Tablet, it is crucial to seek medical attention promptly. An overdose can occur if more than the prescribed amount of this medication is consumed. Consulting your doctor right away or going to the nearest hospital is vital in such cases. Immediate medical intervention is necessary to manage any potential risks associated with an overdose of Kombiglyze XR 5mg/500mg Tablet.


Related lab tests

Related Lab Tests:

For monitoring and managing your condition while taking Kombiglyze XR 5mg/500mg Tablet, your healthcare provider may order the following lab tests:

1. Glucose - Fasting Blood Test: This test measures your blood sugar levels after fasting for a certain period, usually overnight. It helps in evaluating your baseline glucose levels.

2. Glucose - Postprandial Blood Test: This test measures your blood sugar levels 2 hours after a meal. It helps to assess how well your body processes sugar after eating.

3. Glycosylated Hemoglobin Test: Also known as HbA1c test, this measures your average blood sugar levels over the past 2-3 months. It provides an overall picture of your long-term blood sugar control.

These lab tests are essential for monitoring the effects of Kombiglyze XR on your blood sugar levels and overall health. Your healthcare provider will recommend how often you need to undergo these tests based on your individual needs and treatment plan.


Additional Information

Habit FormingNo
Chemical Class-
Therapeutic ClassANTI DIABETIC
Action Class-

FAQs


Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

396.5

Inclusive of all taxes

Content verified by

chevron-right

Dr. Monie Riju Simon

MBBS - General Medicine

Last update on 11-Feb-2025