Holoxan 500mg Injection

By Holoxan

Rx

1 Injection in a Vial

Composition icon

Composition

Ifosfamide(500mg)

Manufacturer - Zydus Cadila icon

Manufacturer - Zydus Cadila

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Expires on or after icon

Expires on or after

September, 2025

About Holoxan 500mg Injection

Holoxan 500mg Injection is a medication used in treating various types of cancers such as blood, breast, lung, ovaries, pancreas, testes, and lymph nodes. It is often administered either alone or in conjunction with other chemotherapy drugs, radiotherapy, or surgical procedures to combat cancer effectively.

This injection is typically delivered as a slow infusion into a vein over the course of several hours. The dosage and frequency of administration will be determined by your doctor based on your specific condition. It is crucial to follow your doctor's instructions precisely to avoid severe side effects that may arise from improper use or overconsumption of the medication.

It may take some time, possibly weeks or months, for the full benefits of Holoxan 500mg Injection to become noticeable. It is essential to continue the treatment as advised by your doctor and not discontinue it abruptly. To help prevent bladder and kidney issues and maintain proper kidney function, it is recommended to increase your fluid intake while on this medication.

Some of the common side effects associated with this medication include nausea, vomiting, anemia, hair loss, and decreased white blood cell count. If these symptoms become bothersome or severe, it is important to inform your doctor. Holoxan 500mg is a potent medication, and it may lead to serious side effects affecting your immune system and various organs like the blood, liver, or kidneys.

Prior to starting treatment with Holoxan 500mg Injection, inform your doctor about any existing liver or kidney conditions and disclose all medications you are currently taking, especially those for treating infections. Due to potential interactions, it is essential to provide a comprehensive list of your medications. It is advised to avoid pregnancy or breastfeeding while on this medication, as it may pose risks to the unborn baby. Additionally, it is recommended to use appropriate contraception methods for a specified time post-treatment to avoid potential harm to the offspring.


Benefits

Holoxan 500mg Injection offers a range of important benefits in treating various types of cancers. In pancreatic cancer, this medicine is effective in controlling the disease and alleviating symptoms like loss of appetite and unexplained weight loss. By targeting the chemicals that promote the growth and spread of pancreatic cancer, Holoxan 500mg Injection plays a crucial role in extending and improving patients' lives.

For ovarian cancer, Holoxan 500mg Injection is instrumental in combating this aggressive disease that often presents at advanced stages. By halting the growth of cancer cells and inhibiting their multiplication, this medication offers a fighting chance against ovarian cancer that tends to spread rapidly to nearby regions like the pelvis and stomach. Despite its effectiveness, it is essential to discuss the potential side effects with your healthcare provider and adhere to recommendations such as avoiding alcohol consumption and staying hydrated through adequate water intake.

In the case of breast cancer, Holoxan 500mg Injection is a valuable treatment option that can be used alone or in combination with other therapies like chemotherapy. By targeting and destroying cancer cells while preventing their proliferation, this medication helps in alleviating symptoms such as breast lumps and changes in breast texture. Patients are encouraged to communicate any concerning side effects to their doctor for proper management.

In non-small cell lung cancer, Holoxan 500mg Injection is utilized to combat this significant type of lung cancer affecting both smokers and non-smokers. It can be administered alone or in conjunction with other medications to effectively target cancer cells. Due to its potency, patients are advised to have a thorough discussion with their healthcare provider regarding the benefits and risks of treatment, while also maintaining hydration and abstaining from alcohol consumption.

For testicular cancer, which impacts the male reproductive organs, Holoxan 500mg Injection proves crucial in stopping the growth and multiplication of cancer cells. This treatment is administered by healthcare professionals and should not be self-administered to ensure proper dosing and monitoring.

Lastly, in blood cancer, also known as leukemia, Holoxan 500mg Injection serves as a potent weapon against cancer cells, preventing their growth and multiplication. Patients receiving this treatment should engage in open discussions with their doctors to weigh the potential risks and benefits, while following recommendations to avoid alcohol and stay adequately hydrated.

Overall, Holoxan 500mg Injection offers a lifeline in the treatment of various cancers, providing patients with hope, extended longevity, and improved quality of life.


How to use the Holoxan 500mg Injection

To use Holoxan 500mg Injection, you should always have a medical professional like a doctor or a nurse administer it to you. It is important not to try to give yourself the injection on your own. Follow the instructions given by your healthcare provider carefully to ensure the medication is administered correctly. Holoxan 500mg Injection should not be self-administered to avoid any potential risks or complications. By having a trained healthcare professional administer the injection, you can be confident that the medication is being given safely and effectively. Remember, always consult your doctor or nurse for the proper use of Holoxan 500mg Injection to ensure your safety and well-being.


Uses of Holoxan 500mg Injection

Holoxan 500mg Injection is utilized in the treatment of various types of cancers, including pancreatic, ovarian, breast, non-small cell lung, testicular, and blood cancer. It is an important medication in the fight against these diseases, offering relief to patients by targeting malignant cells and hindering their growth. Holoxan 500mg Injection is a crucial component of cancer therapy, particularly for those undergoing treatment for the mentioned types of cancer. It plays a significant role in helping patients combat the detrimental effects of these aggressive diseases.


What conditions Holoxan 500mg Injection treats?

Holoxan 500mg Injection is used in the treatment of various cancers like blood, breast, lung, ovaries, pancreas, testes, and lymph nodes. For pancreatic cancer, it helps control the disease and relieve symptoms like lack of appetite. In ovarian cancer, it stops the growth of cancer cells and prevents multiplication, while in breast cancer, it treats symptoms like breast lumps. Non-small cell lung cancer and testicular cancer are also treated with Holoxan to combat cancer cell growth. It is important to discuss the risks and benefits with your doctor and stay hydrated during the treatment.


Should you consult a doctor?

Seek medical attention if you experience persistent or severe side effects from Holoxan 500mg Injection, such as ongoing nausea, vomiting, anemia, hair loss, decreased white blood cell count, or signs of infection. Also, if you notice blood in your urine or symptoms of CNS toxicity, it is important to consult your doctor. Since this medicine can affect your liver, kidneys, and ability to fight infections, it is crucial to seek medical advice if you have existing liver or kidney issues, or if you are taking medications for infections. This injection is not recommended during pregnancy or breastfeeding to prevent harm to the baby. If you or your partner plan on conceiving, it is advisable to wait several months after completing the treatment. Remember to discuss all your medications with your doctor due to potential interactions with Holoxan. If side effects persist or if you have any concerns, do not hesitate to seek medical guidance for proper evaluation and management.


Side effects of Holoxan 500mg Injection

Side effects may occur with Holoxan 500mg Injection but usually do not need medical attention and can go away as your body gets used to the medication. It is essential to talk to your doctor if you experience persistent side effects or are concerned about them. Some of the potential side effects of Holoxan 500mg Injection include nausea, vomiting, anemia (low red blood cell count), hair loss, decreased white blood cell count, infection, blood in urine, and CNS toxicity. If you have any worries about these side effects or if they continue, consult your healthcare provider for guidance.


Safety advice

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liver

Holoxan 500mg Injection needs to be used cautiously in individuals with liver disease. It may be necessary to adjust the dosage of Holoxan 500mg Injection for these patients. It is important to consult with your doctor regarding the use of Holoxan 500mg Injection to ensure proper management and monitoring in case of liver issues.

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kidney

Holoxan 500mg Injection requires caution in individuals with kidney disease. Dosage adjustment may be necessary. It is advised to consult your doctor before use.

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alcohol

It is not safe to drink alcohol while using Holoxan 500mg Injection.

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driving

Holoxan 500mg Injection may cause side effects that could impact driving ability.

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pregnancy

Holoxan 500mg Injection is not safe during pregnancy due to the risk to the developing baby. However, in life-threatening situations, a doctor might prescribe it if benefits outweigh risks. Consult your doctor before use.

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breastfeeding

Holoxan 500mg Injection is not recommended during breastfeeding as it may pose a risk of toxicity to the baby.


Consumption warning before consuming Holoxan 500mg Injection

Before consuming Holoxan 500mg Injection, it is crucial to be aware of certain important considerations. This medication is primarily used in the treatment of various types of cancers, such as those affecting the blood, breast, lung, ovaries, pancreas, testes, and lymph nodes. It is administered through a slow intravenous infusion, with the dosage and frequency determined by your doctor based on your specific condition. It is imperative to strictly follow your doctor's instructions regarding the administration of this medication, as incorrect usage or overdose can lead to severe side effects.

Possible side effects of Holoxan 500mg Injection include nausea, vomiting, anemia, hair loss, and a decreased count of white blood cells. If you experience any of these side effects or find them concerning, it is essential to inform your doctor promptly. This medication is potent and may impact your body's ability to fight infections, potentially causing issues with your blood, liver, or kidneys. Prior to taking Holoxan 500mg Injection, inform your doctor about any existing liver or kidney conditions, as well as any ongoing treatment for infections, as interactions can occur.

Moreover, it is important to note that Holoxan 500mg Injection is not recommended during pregnancy or while breastfeeding, as it can pose risks to the baby. It is advised to avoid pregnancy for a few months following the conclusion of treatment with this medication. Maintaining proper hydration by increasing fluid intake is also recommended to support kidney function and reduce the risk of bladder problems. If in doubt or experiencing any concerning symptoms, always consult your healthcare provider.


What if you forgot to take Holoxan 500mg Injection?

If you forget to take your scheduled dose of Holoxan 500mg Injection, try to take it as soon as you remember. But, if it's close to the time for your next dose, then it's best to skip the missed dose and continue with your usual dosing schedule. Remember not to take a double dose to make up for the missed one. It's important to stick to the correct dosing regimen prescribed by your healthcare provider for the best outcomes.


Related lab tests

When using Holoxan 500mg Injection, it is important to monitor certain lab tests to assess treatment response and potential side effects. The recommended related lab tests include:

1. Beta Human Chorionic Gonodotropin (Beta hCG) - This test is often used as a tumor marker, particularly in cases of certain cancers such as testicular, ovarian, or placental cancers.

2. Breast Cancer Markers (CA 15.3/ ER/ PR) - These tests help in monitoring breast cancer progression and response to treatment by measuring specific markers like CA 15.3 (Cancer Antigen 15-3) and hormone receptors ER (Estrogen Receptor) and PR (Progesterone Receptor).

3. Carcinoembryonic Antigen (CEA) - CEA is a tumor marker commonly used to monitor treatment response and detect recurrence in various types of cancer, including colorectal, pancreatic, and breast cancer.

4. Complete Blood Count (CBC) - This test provides important information about various blood components, such as red blood cells, white blood cells, and platelets, and can help identify potential medication-related adverse effects, such as anemia or low platelet count.

5. Peripheral Smear Examination - This test helps in evaluating the morphology of blood cells to detect any abnormalities or signs of infection, anemia, or other blood disorders.

Regular monitoring of these related lab tests can provide valuable insights into the patient's response to Holoxan 500mg Injection and assist healthcare providers in adjusting treatment as necessary.


Additional Information

Habit FormingNo
Chemical ClassSynthetic analogue of the nitrogen mustard cyclophosphamide
Therapeutic Class-
Action ClassAlkylating agent

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Mansi Chaudhari

MBBS - General Medicine

Last update on 11-Feb-2025