Espra XN Tablet
By Espra XN
Rx
10 Tablet in a Strip

Composition
Naproxen(375mg) + Esomeprazole(20mg)

Manufacturer - Zydus Cadila
Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Expires on or after
July, 2026
About Espra XN Tablet
Espra XN Tablet is a combination medicine aimed at relieving pain and inflammation in various conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It can also be used to alleviate muscle pain, back pain, toothache, or pain in the ear and throat. Espra XN Tablet should be taken with food to prevent stomach upset. The dosage of this medicine should be as per the doctor's advice, and you should not exceed the recommended duration or amount of intake.
The primary components of Espra XN 500 Tablet 10's are Naproxen and esomeprazole, falling under the category of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or painkillers. Naproxen, an anti-inflammatory drug, functions by inhibiting the body's cyclo-oxygenase (COX) enzyme, which reduces the production of prostaglandins causing pain and swelling. However, Naproxen may lead to gastric discomfort and stomach ulcers. In combination with esomeprazole, a proton pump inhibitor, the production of stomach acid is reduced, thus minimizing the gastric irritation caused by Naproxen alone.
Side effects of Espra XN Tablet may include headache, nausea, vomiting, diarrhea, indigestion, flatulence, and stomach pain. If any of these side effects become bothersome or worsen, it is advisable to consult your doctor. Before starting the treatment, it is crucial to inform your doctor about any history of ulcers, high blood pressure, or issues with heart, kidneys, or liver. Pregnant or breastfeeding women should seek medical advice, and alcohol consumption should be avoided while taking this medication.
Individuals with allergies to Naproxen, esomeprazole, or other NSAIDs, a history of ulcers due to painkillers, heart rhythm problems, or certain medical conditions such as liver diseases should exercise caution and consult a doctor before using Espra XN 500 Tablet 10's. Patients above 65 years of age or with pre-existing cardiac diseases, gastrointestinal bleeding, respiratory diseases, kidney diseases, or bleeding disorders are advised to take Espra XN 500 Tablet 10's only under medical supervision. It is essential to keep your doctor informed about your health condition and ongoing medication before initiating Espra XN 500 Tablet 10's to prevent any potential side effects.
Benefits
Espra XN Tablet provides various benefits in pain relief and inflammation management. It is particularly effective in conditions like rheumatoid arthritis and osteoarthritis, where it helps to reduce swelling and alleviate inflammation. Additionally, Espra XN Tablet offers relief from muscle and back pain, toothache, as well as pain in the ear and throat. The tablet works by targeting the substances in the body that are responsible for causing pain and swelling, providing much-needed comfort to individuals suffering from these conditions. Moreover, Espra XN Tablet contains an antacid component that helps prevent acidity that may arise as a side effect of the medication, ensuring better tolerance and compliance with the treatment.
The key components of Espra XN Tablet, Naproxen, and esomeprazole play critical roles in enhancing its effectiveness. Naproxen acts as both an anti-inflammatory agent, reducing inflammation, and an analgesic, relieving pain. It works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body, which is instrumental in the production of pain and swelling-causing chemical substances known as prostaglandins. This mechanism helps in alleviating mild to moderate pain and inflammation at the affected site, thereby reducing joint stiffness. Espra XN Tablet is also beneficial in treating conditions such as fibrositis, tenosynovitis, low back pain, strains, and sprains.
Moreover, the combination of Naproxen with esomeprazole offers additional advantages. While NSAIDs like Naproxen can lead to gastric discomfort, acidity, and an increased risk of stomach ulcers, the addition of esomeprazole helps mitigate these concerns. Esomeprazole, a proton pump inhibitor, works by inhibiting gastric acid secretion, thereby reducing stomach acid production during extended treatment periods. This is especially beneficial for individuals with pre-existing stomach ulcers or those prone to developing stomach ulcers while using NSAIDs. By combining Naproxen with esomeprazole, Espra XN Tablet not only effectively alleviates pain but also minimizes the potential gastric irritation that may occur when Naproxen is taken alone. Overall, the comprehensive benefits of Espra XN Tablet make it a valuable option for individuals seeking relief from various pain and inflammation-related conditions while ensuring gastrointestinal comfort during the treatment course.
How to use the Espra XN Tablet
When using Espra XN Tablet, it is important to follow your doctor's instructions regarding the dose and duration of the medication. The tablet should be swallowed whole with a glass of water. Remember not to chew, crush, or break the tablet before swallowing it. It is recommended to take Espra XN Tablet with food to help maximize its effectiveness. By taking the medication as directed and following these simple guidelines, you can ensure that you are using Espra XN Tablet correctly and safely to achieve the desired results.
Uses of Espra XN Tablet
Espra XN Tablet is primarily used for providing relief from pain. It is an effective medication commonly used to alleviate various types of pain. Whether it is mild or moderate pain, Espra XN Tablet is known to help in reducing discomfort and promoting comfort. This medication targets the source of the pain, providing quick and reliable relief for the individual.
What conditions Espra XN Tablet treats?
Espra XN Tablet is used to treat conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Osteoarthritis is a joint disease where the protective cartilage breaks down, causing pain and stiffness. Rheumatoid arthritis is an autoimmune disease that leads to joint pain and damage. Ankylosing spondylitis causes pain and stiffness in the spine, leading to decreased flexibility and a hunched posture. These conditions can greatly impact a person's quality of life, and Espra XN Tablet helps in managing the symptoms associated with these conditions.
Should you consult a doctor?
If you experience any severe side effects such as persistent headache, persistent nausea, persistent vomiting, persistent diarrhea, persistent indigestion, persistent flatulence, or persistent stomach pain while taking Espra XN Tablet, it is important to seek medical attention. Additionally, if you develop any flu-like symptoms that are troublesome or do not go away, consulting your doctor is recommended. Remember, it is crucial to inform your doctor about any medical history of ulcers, high blood pressure, heart, kidney, or liver issues before taking this medicine. Pregnant or breastfeeding women should consult their doctor before starting treatment with Espra XN Tablet. Avoid alcohol consumption while on this medication as it may lead to excessive drowsiness. It is essential to follow your doctor's advice on the dosage and duration of Espra XN Tablet to avoid any potential complications.
Side effects of Espra XN Tablet
When taking Espra XN Tablet, you may experience a range of side effects. Common side effects may include headache, nausea, vomiting, diarrhea, indigestion, flatulence, stomach pain, and flu-like symptoms. These side effects are typically mild and temporary, resolving as your body becomes accustomed to the medication. However, if these symptoms persist or cause concern, it is important to seek advice from your doctor. In some cases, more uncommon side effects such as confusion, ringing in the ears, changes in vision, tiredness, dizziness, and rashes may occur. If you experience any of these less common side effects, it is recommended to consult with your healthcare provider for further evaluation and guidance.
Safety advice

liver
Espra XN Tablet needs to be used carefully in individuals with liver disease. It may require adjusting the dosage of the tablet. It's important to consult with your doctor regarding the use of Espra XN Tablet if you have liver issues.

kidney
Espra XN Tablet requires caution in patients with kidney disease. Dosage adjustment may be necessary. Consult your doctor.

alcohol
It is not safe to drink alcohol while taking Espra XN Tablet.

driving
Caution - Driving Espra XN Tablet may cause dizziness, sleepiness, fatigue, and vision issues, impacting driving ability.

pregnancy
Espra XN Tablet is not recommended during pregnancy as animal studies suggest potential harmful effects on the developing baby. Consult with your doctor for a thorough evaluation of benefits versus risks before using.

breastfeeding
Espra XN Tablet is considered safe to use while breastfeeding. Studies show that the drug does not pass into breastmilk in significant amounts, posing no harm to the baby.
Consumption warning before consuming Espra XN Tablet
Before taking Espra XN 500 Tablet 10's, avoid it if you have an allergy to this medication. Long-term use of NSAIDs like naproxen, found in Espra XN 500 Tablet 10's, can elevate the risk of heart attack, stroke, and stomach ulcers. If you have a history of ulcers, bleeding disorders, are elderly, alcoholic, or have multiple diseases, the likelihood of developing ulcers is higher. Elderly patients are more susceptible to gastrointestinal bleeding, so their dosage should be limited by a doctor. Avoid using Espra XN 500 Tablet 10's if you have recently had or are planning to undergo heart bypass surgery. Pregnant women, especially in the third trimester, should refrain from taking this medication to avoid harm to the baby. Consulting a doctor is recommended for pregnant or breastfeeding women before starting Espra XN 500 Tablet 10's. Children should not take this medication without a doctor's prescription. Do not take other NSAIDs for pain relief with Espra XN 500 Tablet 10's unless advised. Prolonged use of proton pump inhibitors like esomeprazole in Espra XN 500 Tablet 10's may lead to bone fragility, so consider taking Vitamin D and calcium as recommended by your doctor. Consuming alcohol with Espra XN 500 Tablet 10's can heighten the risk of stomach bleeding or ulcers.
Disease interactions
Espra XN 500 Tablet 10's may interact with certain conditions, so it's important to consult a doctor before taking this medication if you have diabetes, stomach ulcer, gastrointestinal bleeding, asthma, kidney, liver, or heart problems. Additionally, individuals with autoimmune conditions like systemic lupus erythematosus, colitis, or Crohn’s disease should also seek medical advice before starting Espra XN. These conditions can have varying symptoms such as joint pain, fever, skin rashes, swelling of the bowel, diarrhoea, bowel pain, vomiting, and weight loss, which may be impacted by the use of Espra XN Tablet. It is essential to prioritize your health and safety by discussing your medical history with a healthcare professional before initiating treatment with Espra XN 500 Tablet 10's.
What if you forgot to take Espra XN Tablet?
If you forget to take a dose of Espra XN Tablet, try to take it as soon as you remember. But if it's nearly time for your next scheduled dose, it's best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for the missed one. It's important to maintain consistency in taking your medication to ensure its effectiveness.
Additional Information
Habit Forming | No |
Chemical Class | - |
Therapeutic Class | PAIN ANALGESICS |
Action Class | - |
FAQs
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₹132.8
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Content verified by

Dr. Abdullah Khan
MBBS - General Medicine
Last update on 11-Feb-2025