Denu Injection

By Denu

Rx

1ml Injection in a Prefilled syringe

Composition icon

Composition

Denosumab(60mg/ml)

Manufacturer - Alkem Laboratories Ltd icon

Manufacturer - Alkem Laboratories Ltd

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Expires on or after icon

Expires on or after

August, 2025

About Denu Injection

Denu Injection is a medication prescribed for treating osteoporosis in postmenopausal women and men at higher risk of fractures. It is designed to strengthen bones and reduce the likelihood of fractures. This injection should only be administered by a healthcare professional and should not be taken without proper medical guidance. To benefit the most from Denu Injection, it is essential to use it consistently at the same time each day. Even if one feels better, it is crucial to complete the prescribed dose as directed by the doctor.

Taking calcium and vitamin D supplements along with Denu Injection can enhance its effectiveness. However, like any medication, there can be side effects. Common side effects may include pain in extremities, musculoskeletal pain, nerve pain, urinary tract infections, constipation, and rash. If any of these side effects persist or worsen, consulting with a healthcare provider is recommended for guidance on managing or alleviating these symptoms.

Before starting Denu Injection, it is important to inform the doctor about all other medications being taken to ensure its safety and effectiveness. Pregnant and breastfeeding mothers should seek advice from their healthcare providers before using this medication due to potential risks. Furthermore, Denu Injection belongs to a group of medications known as RANK ligand inhibitors, primarily used to combat osteoporosis in postmenopausal women and men at risk of fracturing bones.

Denu 60 mg Injection 1 ml contains denosumab, a key component that works by blocking specific receptors in the body responsible for bone loss. This action helps in strengthening bones and reducing the likelihood of fractures. In addition to osteoporosis, Denu 60 mg Injection 1 ml also aids in treating bone loss due to various factors like reduced testosterone levels post-surgery, use of specific medications such as glucocorticoids, or in patients with prostate cancer.

Moreover, Denu 60 mg Injection 1 ml may be utilized to reduce fracture risks in individuals with conditions like multiple myeloma, giant cell tumor of the bone, and to address high calcium levels due to cancer. Healthcare professionals will administer Denu 60 mg Injection 1 ml, as self-administration is not recommended. It is important to note that some individuals may experience side effects like bone, joint, or muscle pain, abdominal discomfort, and constipation, among others.

To mitigate the risk of osteonecrosis of the jaw, maintaining good dental hygiene and receiving regular dental check-ups during Denu 60 mg Injection 1 ml treatment is advised. It is vital to avoid using this medication during pregnancy and consult a doctor if breastfeeding. Additionally, this medication is not recommended for those under 18 years of age due to lack of established safety and efficacy data. Always keep the healthcare provider informed about health conditions and medications to avoid any potential interactions.


Benefits

Denu Injection, specifically Denu 60 mg Injection 1 ml, is a valuable treatment option for individuals suffering from osteoporosis, a condition characterized by weakened bones that are more prone to fractures, particularly in women post-menopause. This medication plays a crucial role in slowing down the process of bone breakdown in the body, thereby maintaining bone density and reducing the risk of fractures.

Primarily used in postmenopausal women and men at high risk of fractures, Denu Injection is effective in treating bone loss resulting from factors such as hormonal changes due to surgery, medication side effects, or underlying health conditions like prostate cancer. Moreover, patients undergoing long-term glucocorticoid treatment can benefit from Denu Injection to help prevent bone loss and reduce the likelihood of fractures.

The mechanism of action of Denu 60 mg Injection 1 ml involves binding to a specific protein on osteoclasts, the cells responsible for bone breakdown, and inhibiting their formation and function. By impeding the activity of these cells, Denu Injection effectively reduces bone breakdown, boosts bone density, and enhances bone strength. Additionally, in cases of giant cell tumors of the bone (GCTB), Denu Injection works by targeting receptors in the tumor cells, slowing down tumor growth and offering therapeutic benefits.

Beyond treating osteoporosis, Denu Injection is also indicated for reducing fracture risks in individuals with conditions such as multiple myeloma and high calcium levels associated with cancer. By decreasing bone breakdown and enhancing bone integrity, Denu Injection aids in fortifying bones and reducing the likelihood of fractures, ultimately improving the overall bone health of patients.

To complement the benefits of Denu Injection, individuals are encouraged to engage in regular weight-bearing exercises, consume a diet rich in calcium and Vitamin D, and minimize alcohol and tobacco intake. Additionally, supplements of calcium and Vitamin D3 can further support bone strength and health, offering a holistic approach to managing osteoporosis and related bone conditions.

Overall, Denu Injection emerges as a promising therapeutic option that not only addresses bone health concerns but also enhances the quality of life for individuals battling osteoporosis and related bone disorders. By harnessing its bone-strengthening properties and inhibitory effects on bone breakdown, Denu Injection stands as a valuable asset in the management of osteoporosis and associated conditions.


How to use the Denu Injection

When using Denu 60 mg Injection, it is important to note that you should not self-administer this medicine. Your doctor or nurse will give you the injection, typically at a healthcare facility. The injection will be given in a precise measurement of 1 ml by a trained healthcare professional. It is crucial to follow the instructions and not try to administer the injection on your own. By entrusting a healthcare provider to administer Denu Injection, you ensure proper and safe usage of the medication for your health needs.


Uses of Denu Injection

"Denu Injection" is used to address various medical conditions related to bones and calcium levels. It is particularly effective in treating osteoporosis, a condition characterized by bone loss leading to weakened and brittle bones. This injection is also beneficial in managing giant cell tumors of the bone and high calcium levels in the body. By targeting these specific issues, Denu Injection provides a comprehensive approach to maintaining bone health and addressing related concerns.


What conditions Denu Injection treats?

Osteoporosis is a bone disease that leads to weakened and thin bones due to reduced bone density. Postmenopausal women are at higher risk as their estrogen levels decrease after menopause, affecting bone health. This condition can also affect men due to aging or low testosterone levels. Common symptoms include back pain from fractures, gradual height loss, stooped posture, and bones breaking easily.


Should you consult a doctor?

If you experience side effects such as musculoskeletal pain, pain in extremities, nerve pain, constipation, rash, or urinary tract infection while using Denu Injection, it is important to consult your doctor. Although most side effects may resolve as your body adapts to the medication, persistent or worsening symptoms should prompt you to seek medical attention. Additionally, it is crucial to inform your doctor about all other medications you are taking before starting Denu Injection to ensure its safety and effectiveness. Pregnant or breastfeeding women should always consult their doctors before using this medication to avoid any potential risks. It is also essential to take the injection regularly at the same time each day as prescribed by your healthcare provider for optimal benefits in strengthening bones and reducing fracture risks. Remember to complete the full dose as instructed, even if you start feeling better. To enhance the effectiveness of the treatment, consider taking calcium and vitamin D supplements as recommended by your doctor.


Side effects of Denu Injection

When using Denu Injection, you may experience various side effects that can occur as your body gets used to the medicine. Some common side effects include musculoskeletal pain, such as bone, muscle, or joint pain, as well as pain in the extremities like arms or legs. Nerve pain, constipation, rash, and urinary tract infections are also potential side effects of Denu Injection. Other possible side effects to watch for include abdominal discomfort, painful or frequent urination, upper respiratory tract infections, eczema, and even hair loss. If any of these side effects persist or if you have concerns about them, it is essential to consult with your doctor for proper guidance and support.


Safety advice

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liver

Based on the limited data available, it appears that Denu Injection is likely safe for individuals with liver disease. There may not be a requirement for adjusting the dose of Denu Injection in these patients. However, it is important to speak with your doctor if you have liver impairment or any specific concerns related to this issue. Consulting your healthcare provider will ensure proper guidance and monitoring while using Denu Injection.

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kidney

Denu Injection is considered safe for patients with kidney disease. No dose adjustment is needed. Consult your doctor if you have kidney issues or any concerns.

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alcohol

When taking Denu Injection, consult your doctor about alcohol consumption as the interaction is not clear. It's important to be cautious.

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driving

Denu Injection typically does not impact driving ability. 1 ml of Denu 60 mg Injection usually does not affect driving but operate machinery when fully alert.

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pregnancy

Denu Injection is not safe to use during pregnancy. Studies have shown harmful effects on the developing baby. It is advised to consult your doctor before using Denu Injection. If you are a woman who can bear a child, use reliable contraception during the treatment and for 5 months after stopping it. Notify your doctor if you are pregnant, suspect you are pregnant, or are planning for pregnancy.

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breastfeeding

Denu Injection appears to be safe during breastfeeding based on limited data. It's advised to consult your doctor before using Denu 60 mg Injection 1 ml while breastfeeding.


Consumption warning before consuming Denu Injection

Before using Denu Injection, ensure you are not allergic to any of its components or have hypocalcaemia (low blood calcium levels). Inform your doctor about any existing conditions such as low calcium levels, kidney or liver problems, poor dental or gum health, weak immune system, hypoparathyroidism, malabsorption, latex allergy, thyroid surgery history, upcoming dental procedures, glucocorticoid use, or inability to take calcium and vitamin D supplements. Refrain from using Denu Injection if you are pregnant, and seek medical advice if you are breastfeeding. This product is not suitable for children under 18 years old due to unestablished safety and efficacy in this age group.


Disease interactions

When considering the use of Denu Injection, it is important to inform your doctor if you have hypocalcaemia, which is low levels of calcium in the blood, or if you are immunosuppressed. These conditions can affect how your body responds to the medication and may require adjustments to your treatment plan. Make sure to communicate openly with your healthcare provider about any existing health conditions to ensure the safe and effective use of Denu Injection.


What if you forgot to take Denu Injection?

If you forget to take a dose of Denu Injection, it is important to consult your doctor for guidance. It is always best to follow your healthcare provider's recommendations when it comes to your treatment. If you have missed a dose, speaking with your doctor can help you understand what steps you should take next to ensure you are still on track with your medication regimen. Remember that your doctor is there to help you navigate any missed doses and provide you with the best advice for your specific situation.


Related lab tests

Related Lab Tests for evaluating the use of Denu Injection may include tests for calcium levels. Calcium is an essential mineral in the body that helps with various biological functions such as bone health, muscle function, and nerve transmission. Testing for calcium levels can help assess if there are any abnormalities that may impact the effectiveness or safety of Denu Injection.

Lab tests for calcium levels typically involve a simple blood test to measure the amount of calcium present in the bloodstream. Abnormal calcium levels can indicate underlying health issues such as bone diseases, kidney problems, or hormonal imbalances. Monitoring calcium levels can be important when considering the use of certain medications or supplements, including Denu Injection.

It is recommended to consult with a healthcare provider to determine the appropriate lab tests based on an individual's medical history and the specific reasons for considering Denu Injection. Regular monitoring of calcium levels and other related lab tests may be necessary to ensure the safe and effective use of Denu Injection.

Related Lab Tests:
- Serum Calcium Level Test
- Ionized Calcium Test
- Total Calcium Test


Additional Information

Habit FormingNo
Chemical ClassMonoclonal Antibody
Therapeutic ClassPAIN ANALGESICS
Action ClassBone resorption inhibitors- Monoclonal antibodies

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Abdullah Khan

MBBS - General Medicine

Last update on 11-Feb-2025