Darzalex 400mg Injection
By Darzalex
Rx
1 Injection in a Vial

Composition
Daratumumab(400mg)

Manufacturer - Janssen Pharmaceuticals
Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Expires on or after
May, 2026
About Darzalex 400mg Injection
Darzalex 400mg Injection is a medication used to treat multiple myeloma, a type of cancer that affects plasma cells. It is administered through an intravenous infusion into the veins, under the supervision of a doctor. The dose and frequency of Darzalex 400mg Injection will be determined by your doctor based on your specific condition, and these instructions may be adjusted over time. It is crucial to follow your doctor's advice carefully, as taking the medication incorrectly or in excessive amounts can lead to serious side effects.
It may take some time, possibly several weeks or even months, for you to notice the benefits of Darzalex 400mg Injection, so it is important to continue with the treatment as directed by your doctor without interruption. Common side effects of this medication include infusion reactions, such as swelling of the face, lips, mouth, tongue, or throat, as well as difficulties with swallowing or breathing. Additionally, Darzalex 400mg Injection may cause a decrease in white blood cells, making you more susceptible to infections. Regular blood tests will be necessary to monitor your blood cell levels during treatment.
It is crucial to inform your healthcare team about all the medications you are currently taking, as other drugs may interact with Darzalex 400mg Injection. This medication is not recommended for use during pregnancy or while breastfeeding, and both males and females should use effective contraception while undergoing treatment to prevent pregnancy. Adhering to these precautions will help ensure the safe and effective use of Darzalex 400mg Injection in the treatment of multiple myeloma.
Benefits
Darzalex 400mg Injection provides significant benefits for individuals with multiple myeloma, a condition where the body is breaking down bone faster than it can be replaced, resulting in weak and painful bones that are more prone to fractures. When prescribed alongside other cancer treatments like chemotherapy, Darzalex becomes a vital component of the treatment regimen, ultimately enhancing the survival rate of individuals affected by multiple myeloma. This medication functions by targeting and eliminating cancerous cells, effectively curbing their growth and preventing them from spreading to other parts of the body. To derive the maximum benefit from Darzalex, it is crucial to adhere closely to the instructions provided by your healthcare provider. In addition to the injection, your doctor may also recommend supplements of calcium and Vitamin D3, especially if you do not have elevated levels of blood calcium, as these nutrients play a positive role in supporting bone health. By integrating Darzalex into your treatment plan and following medical advice diligently, you can experience improved outcomes in managing multiple myeloma and fostering overall well-being.
How to use the Darzalex 400mg Injection
To use Darzalex 400mg Injection, it is important to follow the instructions provided by your doctor or nurse. This medication should never be self-administered, and should always be given by a healthcare professional. Before using Darzalex, make sure to thoroughly discuss the treatment plan with your healthcare provider and address any concerns or questions you may have. Your doctor will determine the correct dosage and frequency of the injections based on your individual condition. During the injection, it is normal to experience some discomfort or side effects, so it is important to communicate any reactions to your healthcare provider. Remember to keep all scheduled appointments for your injections to ensure the best possible outcome of the treatment. If you have any doubts or need further clarification on how to use Darzalex 400mg Injection, do not hesitate to reach out to your healthcare team for guidance and support.
Uses of Darzalex 400mg Injection
Darzalex 400mg Injection is commonly used in the treatment of a specific type of cancer known as multiple myeloma. In patients suffering from multiple myeloma, Darzalex is utilized to target and attack cancerous cells, ultimately helping to slow down the progression of the disease. This injection works by attaching itself to a protein in the body known as CD38, which is found in high amounts on myeloma cells. By binding to CD38, Darzalex helps the immune system to identify and kill the cancer cells more effectively. Darzalex is often prescribed by healthcare professionals as part of a comprehensive treatment plan for multiple myeloma patients to help improve their outcomes and quality of life.
What conditions Darzalex 400mg Injection treats?
Darzalex 400mg Injection is used to treat multiple myeloma, a type of cancer that affects plasma cells. In multiple myeloma, the body breaks down bone faster than it can be replaced, leading to weak and painful bones that are prone to fractures. Darzalex, when used along with other cancer treatments like chemotherapy, is vital in increasing survival rates for multiple myeloma patients. This medication targets and eliminates cancerous cells, halting their growth and preventing spread to other body parts. It is crucial to follow your doctor's instructions for optimal results, and calcium and Vitamin D3 supplements may be prescribed if needed.
Should you consult a doctor?
If you experience any severe side effects while taking Darzalex 400mg Injection, it is important to seek medical attention promptly. Notify your doctor immediately if you develop infusion reactions such as swollen face, difficulty swallowing or breathing, or any signs of decreased white blood cell count, which can increase infection risk.
Furthermore, if you encounter persistent or concerning symptoms like severe back pain, dizziness, fatigue, or difficulty breathing, consult your healthcare provider. It is essential to inform your medical team about all medications you are using due to potential interactions.
Moreover, if you are pregnant, breastfeeding, or planning to conceive, consult your doctor before starting this treatment. Proactively discuss the use of effective contraception to prevent pregnancy during the course of Darzalex 400mg Injection.
Regular monitoring and open communication with your healthcare provider are crucial for a safe and effective treatment journey with Darzalex 400mg Injection.
Side effects of Darzalex 400mg Injection
When using Darzalex 400mg Injection, you may experience some side effects, although not everyone will have them. These side effects are usually mild and will go away as your body gets used to the medicine. It's essential to inform your doctor if the side effects persist or if you have any concerns about them. Side effects include back pain, constipation, decreased white blood cell count, diarrhea, dizziness, fatigue, fever, infusion reaction, insomnia, joint pain, low blood platelets, nausea, breathlessness, upper respiratory tract infection, and vomiting. If you encounter any of these side effects, speak with your healthcare provider for guidance and support.
Safety advice

liver
Darzalex 400mg Injection is considered safe for use in individuals with liver disease. The available data indicates that adjusting the dosage of Darzalex 400mg Injection may not be necessary for patients with liver issues. However, it is important to consult with your doctor regarding the use of Darzalex 400mg Injection if you have liver disease.

kidney
Darzalex 400mg Injection is likely safe for patients with kidney disease. Data indicates dose adjustment may not be required. Consult your doctor for guidance.

alcohol
Consult your doctor when cosuming alcohol with Darzalex 400mg Injection.

driving
Darzalex 400mg Injection typically does not impact driving ability.

pregnancy
Darzalex 400mg Injection should be avoided during pregnancy due to potential harm to the baby, as seen in animal studies. Consult your doctor for a thorough evaluation of benefits versus risks before using this medication.

breastfeeding
Darzalex 400mg Injection is likely unsafe while breastfeeding. Limited data indicates it may pass into breastmilk and harm the baby.
Consumption warning before consuming Darzalex 400mg Injection
Before consuming Darzalex 400mg Injection for the treatment of multiple myeloma, it's crucial to heed some important warnings. This medication should only be administered as an intravenous infusion by a qualified healthcare professional. The dosage and frequency will be determined by your doctor based on your specific condition, so follow their instructions carefully to avoid potential serious side effects. Infusion reactions, such as facial swelling or difficulty breathing, are common, and regular blood tests are necessary to monitor blood cell levels. Be cautious about potential drug interactions, as Darzalex may interact with other medications. It is not advisable to use this medication during pregnancy or while breastfeeding, and both men and women should use effective contraception during treatment to prevent pregnancy. Remember, it may take time to experience the benefits of Darzalex, so continue using it as directed by your doctor.
Related lab tests
Related Lab Tests:
When considering the use of Darzalex 400mg Injection, several related lab tests may be recommended to monitor your health and ensure the medication is effective and safe for you. The following lab tests are commonly done and provide important information for your healthcare provider:
1. Albumin/Globulin Ratio, Serum: This test helps to evaluate the balance of proteins in your blood that can indicate various conditions, such as liver or kidney disease, infections, or inflammatory disorders. Monitoring this ratio can give insights into your overall health status and response to treatment.
2. Calcium: Checking your calcium levels is important while on Darzalex 400mg Injection, as imbalances can affect your bone health and nerve function. It helps to ensure that your body is maintaining the right levels of this essential mineral for proper functioning.
3. Complete Blood Count (CBC): This comprehensive test assesses your overall blood health, including the levels of red blood cells, white blood cells, and platelets. Monitoring your CBC can help detect any potential side effects of Darzalex 400mg Injection on your blood cells and ensure your body is coping well with the medication.
4. Kidney Function Test: This test evaluates how well your kidneys are functioning by measuring levels of creatinine, blood urea nitrogen (BUN), and other markers. Since Darzalex 400mg Injection can affect kidney function, monitoring these tests is crucial to prevent any complications and adjust the dosage if necessary.
By regularly checking these related lab tests, your healthcare team can ensure your safety and wellbeing while undergoing treatment with Darzalex 400mg Injection. It is important to follow their recommendations and attend scheduled lab appointments for proper monitoring of your health status.
Additional Information
Habit Forming | No |
Chemical Class | Carboxylic Acid Derivative |
Therapeutic Class | - |
Action Class | - |
FAQs
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₹75500
Inclusive of all taxes
Content verified by

Dr. Mansi Chaudhari
MBBS - General Medicine
Last update on 11-Feb-2025