Bryxta 400 Injection

By Bryxta

Rx

1 Injection in a Vial

Composition icon

Composition

Bevacizumab(400mg)

Manufacturer - Zydus Cadila icon

Manufacturer - Zydus Cadila

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Expires on or after icon

Expires on or after

January, 2026

About Bryxta 400 Injection

Introduction:

Bryxta 400 Injection is a potent anticancer medication used in the treatment of various types of cancer, including cancer of the colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian, cervical cancer, metastatic breast cancer, and more. It works by hindering the growth of new blood vessels that supply nourishment to tumors, thereby halting the growth of these abnormal cells. This injection is considered an effective first-line treatment option when combined with other cancer medicines.

Administration and Dosage:

Bryxta 400 Injection is administered as an infusion, where it is delivered through a small needle in your vein or via a port placed under your skin. Your doctor will determine the appropriate dosage and duration of the treatment based on your medical condition. During the infusion process, it is important for the healthcare provider to monitor any signs of infusion reactions such as high blood pressure and breathing difficulties. Patients are advised to continue the treatment as long as their disease remains under control and side effects are manageable.

Side Effects:

Common side effects of Bryxta 400 Injection may include rectal bleeding, taste changes, and headaches. Patients are encouraged to inform their healthcare provider if they experience any unusual bleeding or bleeding tendencies, as well as before undergoing any surgical procedures. This medication may lower the ability of wound healing and increase the risk of bleeding. Additionally, it is crucial to inform the doctor if you are pregnant, planning a pregnancy, or breastfeeding, as Bryxta 400 Injection can have implications on these conditions. It is also necessary to disclose all medications being used to prevent any potential interactions.

Mechanism of Action:

Bryxta 400 Injection contains Bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor (VEGF) found on the lining of blood vessels. By inhibiting VEGF, this drug limits the growth of new blood vessels within tumors, reducing the oxygen and nutrients supplied to the tumor, ultimately leading to its shrinkage or cessation of growth.

Precautions:

Patients are advised not to self-administer Bryxta 400 Injection and should adhere to the dosage prescribed by their doctor. Consult your healthcare provider if you experience any side effects that persist or worsen over time. Avoid the use of Bryxta 400 Injection if pregnant, and practice effective contraception during treatment and up to six months after the last dose. Refrain from driving if experiencing sleepiness or fainting while on this medication. It is important to communicate openly with your healthcare provider regarding your health condition and all medications being taken to ensure optimal safety and efficacy of the treatment.


Benefits

Bryxta 400 Injection offers a range of benefits in treating various types of cancers. In cases of colon and rectal cancer, it not only treats existing cancer but also reduces the risk of developing further cancerous growths. By killing or inhibiting the growth of cancer cells, Bryxta 400 Injection effectively prevents the multiplication of these harmful cells in the colon or rectum. In non-small cell lung cancer, this medication is effective either alone or in combination with other treatments. It is crucial to discuss the potential risks and benefits with your doctor before starting treatment. Moreover, in kidney cancer, Bryxta 400 Injection addresses symptoms such as blood in urine, weight loss, and fatigue while halting the advancement of cancer to other parts of the body. Similarly, for patients with brain tumors, ovarian cancer, and cervical cancer, this medication works by stopping the growth and multiplication of cancer cells, offering an effective treatment option. However, it is important to note that Bryxta 400 Injection is a potent and toxic medicine, requiring careful adherence to doctor's instructions and a discussion of risks and benefits prior to use.


How to use the Bryxta 400 Injection

To use Bryxta 400 Injection, you should let your doctor or nurse administer the medicine to you. It comes in a 16 ml vial and must be given by a healthcare professional. It is important not to try to administer this injection on your own. This medication is meant to be administered by a trained professional to ensure proper dosage and safe administration. Be sure to follow your healthcare provider's instructions carefully and do not attempt to self-administer this injection. Your well-being is our top priority, and following these guidelines will help ensure the safe and effective use of Bryxta 400 Injection.


Uses of Bryxta 400 Injection

Bryxta 400 Injection is used in the treatment of various types of cancers such as colon cancer, rectal cancer, non-small cell lung cancer, kidney cancer, brain tumor, ovarian cancer, and cervical cancer. It is particularly helpful in managing metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, as well as colorectal cancer. Bryxta 400 Injection plays a crucial role in targeting these specific types of cancer and is considered as part of the treatment plan for patients diagnosed with these conditions.


What conditions Bryxta 400 Injection treats?

Cancer is a disease where cells in a certain body area grow and replicate without control. These cancerous cells can invade and harm nearby healthy tissues and organs. Cancer usually starts in one spot and can spread to other parts of the body. Mutations in genes that control cell growth are what cause cancer to develop. These mutations make cells divide and multiply uncontrollably, leading to the formation of tumors. Treatment options for cancer often include surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy, and targeted drug therapy.


Should you consult a doctor?

If you experience rectal bleeding, changes in taste, headaches, nosebleeds, back pain, dry skin, high blood pressure, protein in urine, or nasal inflammation while taking Bryxta 400 Injection, it is essential to consult your doctor. These symptoms may indicate potential side effects that require medical attention. Additionally, if you notice any unusual bleeding or have concerns about your condition, it is important to seek immediate medical advice. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Bryxta 400 Injection may have implications for these scenarios. Moreover, if you are scheduled for surgery, it is crucial to disclose your medication to avoid complications with wound healing. Be vigilant about any changes in your health status and always communicate openly with your doctor about any concerns or new development while on Bryxta 400 Injection.


Side effects of Bryxta 400 Injection

When using Bryxta 400 Injection, certain side effects may occur as your body gets used to the medication. Common side effects include rectal bleeding, taste changes, headaches, nosebleeds, back pain, dry skin, high blood pressure, presence of protein in urine, and nasal inflammation. Additionally, some users may experience constipation, loss of appetite, fever, nosebleeds, changes in speech, changes in taste perception, hoarseness in voice, and unexplained weight loss. Remember that most side effects are temporary and will fade over time, but if they persist or cause concern, do not hesitate to consult your healthcare provider.


Safety advice

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liver

Bryxta 400 Injection appears to be safe for use in individuals with liver disease, as per the limited data available. It is suggested that adjusting the dosage of Bryxta 400 Injection may not be necessary for patients with liver issues. It is advisable to consult your doctor before using this medication to ensure it is suitable for your specific condition.

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kidney

Bryxta 400 Injection is likely safe for use in patients with kidney disease. Available data suggests no need for dose adjustment. Consult your doctor for guidance.

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alcohol

It is not certain if it is safe to drink alcohol while taking Bryxta 400 Injection. Please consult your doctor.

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driving

Be cautious when driving after using Bryxta 400 Injection due to reported side effects like sleepiness and fainting, which can affect your driving ability.

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pregnancy

Bryxta 400 Injection may not be safe to use during pregnancy. Limited human studies and animal studies have shown negative effects on the developing baby. Your doctor will consider the benefits and risks before prescribing it to you. Please consult your doctor before using Bryxta 400 Injection.

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breastfeeding

Bryxta 400 Injection is likely unsafe during breastfeeding. Limited data indicates it may pass into breastmilk and harm the baby.


Consumption warning before consuming Bryxta 400 Injection

Before consuming Bevarest-400 Injection 16 ml, it is crucial to seek medical supervision for your safety. Your doctor will closely monitor your condition during the treatment. Inform your doctor about any past allergic reactions to Bryxta 400 Injection or other medications. If you are pregnant, it is advised to avoid taking Bryxta 400 Injection and use effective contraception during the treatment and for 6 months after the last dose. Be aware that this injection may cause drowsiness and fainting, so refrain from driving while undergoing treatment. Notify your doctor if you have a history of high blood pressure, heart attack, stroke, bleeding disorders, or recent surgeries. Avoid breastfeeding during the treatment period and for 6 months after the final dose. Additionally, do not receive any vaccinations without your doctor's approval as Bryxta 400 Injection may elevate the risk of bleeding. If you experience unusual bleeding or bruising, consult your doctor immediately.


Disease interactions

When using Bryxta 400 Injection, it is crucial to inform your healthcare provider about any previous or current infections, bleeding disorders, fistula formation, GI perforation, hypertension, PRES (Posterior Reversible Encephalopathy Syndrome), proteinuria, and thromboembolic disorders. These conditions can potentially interact with the medication, affecting its effectiveness or causing adverse reactions. By disclosing this information to your doctor, they can make informed decisions about the appropriateness of Bryxta 400 Injection for your specific health circumstances. It is important to prioritize your safety and well-being by ensuring open communication with your healthcare provider regarding any pre-existing medical conditions.


What if you forgot to take Bryxta 400 Injection?

If you forget to take a dose of Bryxta 400 Injection, it is important to speak with your doctor without delay. Consulting your doctor is essential to ensure you receive proper guidance on how to proceed after missing a dose of this medication. It is crucial not to take any extra doses to make up for the missed one without first consulting with your healthcare provider. Your doctor will be able to provide you with the necessary advice tailored to your specific situation.


Related lab tests

When considering 'Bryxta 400 Injection', there are several related lab tests that may be important to consider. These include Carcino Embryonic Antigen, which is a blood test that can help in monitoring certain types of cancer. Another essential test is the Complete Blood Count (CBC), which provides information on different components of the blood like red blood cells and white blood cells. Human Papilloma Virus (HPV) testing can help in detecting the presence of this virus which is linked to certain types of cancers. Additionally, the Papanicolaou (PAP) Cytology test, commonly known as a Pap smear, is crucial for screening cervical cancer in women. These lab tests play a significant role in assessing health status and detecting potential issues that may require further evaluation or treatment.


Additional Information

Habit FormingNo
Chemical ClassMonoclonal Antibody
Therapeutic Class-
Action Class-

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Abdullah Khan

MBBS - General Medicine

Last update on 01-Oct-2024