Atrest 12.5 Tablet
By Atrest
Rx
10 Tablet in a Strip

Composition
Tetrabenazine(12.5mg)

Manufacturer - Centaur Pharmaceuticals Pvt Ltd
CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.

Expires on or after
August, 2026
About Atrest 12.5 Tablet
Atrest 12.5 Tablet is a medication used to treat chorea, a movement disorder associated with Huntington's disease. This condition is characterized by involuntary, jerky movements. The tablet works by balancing dopamine levels in the body, which helps reduce these movements and improve overall function, making it easier for individuals to move and function better.
It is recommended to take Atrest 12.5 Tablet with or without food, at the same time each day to maintain a consistent level of medicine in the body. It is important to follow the dosage and duration advised by your doctor. If a dose is missed, it should be taken as soon as remembered. Sudden discontinuation of this medication without consulting a doctor may worsen symptoms. Immediate discontinuation is necessary if symptoms of neuroleptic malignant syndrome, characterized by fever, muscle rigidity, altered consciousness, or seizures, occur.
Common side effects of Atrest 12.5 Tablet include nausea, insomnia, anxiety, fatigue, restlessness, depression, dizziness, and sleepiness. It is advised not to drive or engage in activities requiring mental focus until the effects of the medicine are known. Inform your doctor if you experience any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medication.
Atrest 12.5 Tablet belongs to a class of medications called vesicular monoamine transporter 2 (VMAT2) inhibitors and is specifically used in the treatment of Huntington's disease. This genetic condition causes certain nerve cells in the brain to waste away due to defective genes present at birth. The active ingredient in Atrest 12.5 Tablet, tetrabenazine, depletes chemical messengers in the brain that help regulate body movements.
It is important to continue using Atrest 12.5 Tablet as prescribed by a doctor to effectively treat the condition. Common side effects such as nausea, insomnia, anxiety, fatigue, sleepiness, restlessness, and depression generally diminish over time. Consult a doctor if these side effects persist. Before using Atrest 12.5 Tablet, inform your doctor of any allergies, skin reactions to medicines, pregnancy or breastfeeding status, or existing health conditions such as heart, liver, or kidney disorders.
Atrest 12.5 Tablet is not recommended for use in patients allergic to tetrabenazine or those with certain medical conditions such as Parkinson-like symptoms, depression, active suicidal thoughts, pheochromocytoma, or kidney disorders. It should be used with caution in pregnancy, and consulting a healthcare provider is advised before use. The medication is not recommended for children and adolescents under 18 years old and should be used carefully in elderly patients over 65 years old. Common side effects may include confusion, anxiety, sleeplessness, low blood pressure, nausea, vomiting, diarrhea, or constipation, which should be monitored and discussed with a doctor if they worsen.
Benefits
Atrest 12.5 Tablet offers significant benefits for individuals dealing with chorea, a movement disorder commonly linked to Huntington's disease. Chorea is characterized by involuntary, jerky movements, which can greatly impact daily life. This medication effectively treats these symptoms and helps to control the unpredictable movements associated with the condition. By reducing the overactive secretion of chemicals like serotonin, norepinephrine, and dopamine in the brain, Atrest 12.5 Tablet plays a crucial role in addressing the underlying causes of degeneration of nerves that lead to loss of control over thoughts, emotions, and movements.
By regulating these natural substances in the brain that transmit signals between nerves, this medication helps to lower the excessive brain signals responsible for triggering involuntary muscle movements. Ultimately, Atrest 12.5 Tablet can significantly enhance the quality of life for individuals with chorea by improving their ability to carry out daily functions with greater ease and efficiency. Its ability to manage jerky movements and control symptoms associated with Huntington's disease make it a valuable treatment option for those seeking relief and improved functionality in their day-to-day activities.
How to use the Atrest 12.5 Tablet
When using Atrest 12.5 Tablet, it is important to follow your doctor's guidance on the dose and duration of the medication. Swallow the tablet whole with a glass of water. Do not chew, crush, or break the tablet. You can take Atrest 12.5 Tablet with or without food, but it is recommended to take it at the same time every day for consistency. Your doctor will determine the appropriate dosage and duration based on factors such as your age, weight, and specific medical condition. Remember to always follow your physician's instructions carefully to ensure the effectiveness of the medication.
Uses of Atrest 12.5 Tablet
Atrest 12.5 Tablet is used for the treatment of chorea, which is a movement disorder commonly linked to Huntington's disease. It helps in managing the symptoms of hyperkinetic motor disorders experienced by individuals affected by Huntington's disease. These symptoms often include jerky, irregular, and uncontrollable movements. Atrest 12.5 Tablet is specifically designed to address the challenges presented by Huntington's chorea, an inherited neurodegenerative condition.
What conditions Atrest 12.5 Tablet treats?
Atrest 12.5 Tablet is used for Huntington's disease, a condition that causes uncontrolled body movements due to excess natural substances in the brain. This medicine works by reducing these chemicals that impact muscle and nerve activity. Symptoms include sudden, irregular body movements, dizziness, decreased appetite, and difficulty speaking or swallowing. Huntington's disease is inherited from ancestors or immediate family members, not everyone will have it.
Should you consult a doctor?
It is crucial to seek medical attention before taking Atrest 12.5 Tablet if you have Parkinson-like symptoms, untreated or difficult to treat depression, active suicidal thoughts, pheochromocytoma, or prolactin-dependent tumors like pituitary or breast cancer. Additionally, inform your doctor if you are a slow/intermediate metabolizer of the CYP2D6 enzyme or intolerant to sugars like lactose before using Atrest 12.5 Tablet. These conditions require medical guidance to ensure safe and appropriate usage of the medication.
Side effects of Atrest 12.5 Tablet
When taking Atrest 12.5 Tablet, some people may experience side effects. These side effects are usually mild and go away as your body gets used to the medication. Common side effects may include nausea, difficulty sleeping (insomnia), feelings of anxiety, fatigue, sleepiness, and an inability to stay still (akathisia). Additionally, you might also encounter symptoms like depression, confusion, hallucinations, muscle stiffness, fever, drowsiness especially with higher doses, and Parkinson-like movements such as uncontrollable head or limb movements. Other potential side effects include anxiety, sleeplessness, low blood pressure, swallowing difficulties (dysphagia), gastrointestinal issues like nausea, vomiting, diarrhea, or constipation, excessive sweating, and signs of a serious condition called Neuroleptic malignant syndrome, which can present as confusion, hallucinations, muscle stiffness, and changes in body temperature. It's important to stop taking Atrest 12.5 Tablet immediately and seek medical help if you experience feelings of sadness or depression, have suicidal thoughts, or if you are considering harming yourself intentionally. Remember to consult your doctor if any side effects persist or if you are concerned about them.
Safety advice

liver
Atrest 12.5 Tablet may not be safe for individuals with liver disease and is recommended to be avoided. It is advisable to consult a healthcare professional before using this medication to ensure your liver health is not compromised.

kidney
Limited information exists on using Atrest 12.5 Tablet in patients with kidney disease. Caution is advised; consult your doctor before use.

alcohol
When taking Atrest 12.5 Tablet, be cautious as it can make you very sleepy if combined with alcohol.

driving
"Caution - Driving Atrest 12.5 Tablet can decrease alertness, affect vision, and cause drowsiness and dizziness. Avoid driving if experiencing these symptoms."

pregnancy
Atrest 12.5 Tablet should not be used during pregnancy as it may be unsafe. Animal studies suggest potential harm to the developing baby. It is important to consult your doctor for a careful evaluation of the benefits and risks before taking this medication.

breastfeeding
Caution should be taken during breastfeeding while using Atrest 12.5 Tablet. Limited data shows potential harm to the baby as the drug could pass into breast milk.
Age above 75(Geriatrics)
Age below 6 months(Pediatrics)
Consumption warning before consuming Atrest 12.5 Tablet
Before taking Atrest 12.5 Tablet, be aware of potential side effects like changes in mood or behavior, restlessness, or feelings of nervousness. If you experience dizziness, make sure to move slowly. Regular monitoring by a doctor is crucial to track any symptoms or side effects. This medication can lead to severe depression and increase the risk of suicidal thoughts, so it's important to be cautious. Avoid combining Atrest 12.5 Tablet with certain medications like risperidone and MAO inhibitors. If you are already undergoing treatment for severe depression with antidepressants, do not use Atrest 12.5 Tablet.
Disease interactions
For individuals dealing with certain health conditions, caution is advised when considering the use of Atrest 12.5 Tablet. It is not recommended for those with arrhythmias, a condition characterized by an irregular heartbeat, as well as for individuals experiencing depression. Additionally, individuals with liver or kidney diseases should avoid taking this medication. Moreover, those who have Huntington's disease, which is an inherited condition causing nerve cell breakdown in the brain, should also steer clear of Atrest 12.5 Tablet. It is crucial for individuals with these conditions to consult a healthcare professional before initiating any treatment with this medication to prevent adverse reactions and ensure safety.
What if you forgot to take Atrest 12.5 Tablet?
If you forget to take your Atrest 12.5 Tablet, try to take it as soon as you remember. But if it's close to the time for your next dose, just skip the missed one and take the next dose as scheduled. Avoid taking a double dose to make up for the missed one, as this could lead to unwanted side effects. It's important to stick to your regular dosing schedule to ensure the medication works effectively.
What happens if you take overdose of Atrest 12.5 Tablet?
In case of accidentally taking too much ATREST 12.5MG TABLET, it is important to seek immediate medical help. An overdose of this medication may lead to various symptoms such as uncontrollable muscle spasms affecting different parts of the body, including the eyes, head, and neck. Other signs of overdose include uncontrolled rolling of eyes, excessive blinking, nausea, vomiting, diarrhea, sweating, dizziness, feeling cold, confusion, hallucinations, drowsiness, redness or inflammation, and tremors. If you experience any of these symptoms, do not hesitate to consult your doctor or go to the nearest hospital for assistance.
Additional Information
Habit Forming | No |
Chemical Class | Tetrahydroisoquinoline Derivative |
Therapeutic Class | NEURO CNS |
Action Class | Monoamine depletor- Tetrabenazine |
FAQs
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Content verified by

Dr. Archana Prabhakar
MBBS, M.Med (Family Medicine)
Last update on 11-Feb-2025